DegronMD

Uniprot ID: Q3MJ16

Source protein: Cytosolic phospholipase A2 epsilon

Source gene: PLA2G4E

Class: DEG_SCF_FBW7_1

Location: 814:820

E3 ligase: FBXW7

DEGRON score: 0.98

ASA_SCORE: 53.9286

COIL: 0.7499

CONS_SCORE: 0.4435

DSS_SCORE: 0.3701

HELIX: 0.041

FCONS_SCORE: 1.1781

RIG_SCORE: 0.764

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A828T	TCGA-49-AARE	LUAD	TCGA	PKTPYAT	DEG_SCF_FBW7_1	0.1111
p.A828T	DO218922	LUAD	ICGC	PKTPYAT	DEG_SCF_FBW7_1	0.1111
p.D810G	TCGA-AP-A1DV	UCEC	TCGA	PKTPYAT	DEG_SCF_FBW7_1	0.2222
p.D810G	DO43186	UCEC	ICGC	PKTPYAT	DEG_SCF_FBW7_1	0.2222
p.E822K	TCGA-D9-A6EC	SKCM	TCGA	PKTPYAT	DEG_SCF_FBW7_1	0.2778
p.E822K	DO50291	SKCM	ICGC	PKTPYAT	DEG_SCF_FBW7_1	0.2778
p.E805K	TCGA-ER-A194	SKCM	TCGA	PKTPYAT	DEG_SCF_FBW7_1	0.0833
p.E805K	DO47646	SKCM	ICGC	PKTPYAT	DEG_SCF_FBW7_1	0.0833
p.Q806L	DO49667	LIAD	ICGC	PKTPYAT	DEG_SCF_FBW7_1	0.1111
p.Q808R	DO49667	LIAD	ICGC	PKTPYAT	DEG_SCF_FBW7_1	0.1667
p.P814H	DO229027	LICA	ICGC	PKTPYAT	DEG_SCF_FBW7_1	0.7694

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3MJ16	Cytosolic phospholipase A2 epsilon	DEG_SCF_FBW7_1	814:820	PKTPYAT	FBXW7	0.98	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons