DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
PLDTPPDS
Uniprot ID:
A8MUH7
Source protein:
Putative PDZ domain-containing protein PDZK1P1
Source gene:
PDZK1P1
Class:
DEG_SCF_FBW7_1
Location:
360:367
E3 ligase:
FBXW7
DEGRON score:
0.9853
ASA_SCORE:
84.6
COIL:
0.94
CONS_SCORE:
0.3852
DSS_SCORE:
0.5016
HELIX:
0.0336
FCONS_SCORE:
1.099
RIG_SCORE:
0.6669
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with PDZK1P1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PLDTPPDS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5T2W1
Na
DEG_SCF_FBW7_1
477:484
PLDTPPDS
FBXW7
0.9877
More...
A8MUH7
Putative PDZ domain-containing protein PDZK1P1
DEG_SCF_FBW7_1
360:367
PLDTPPDS
FBXW7
0.9853
More...