DegronMD

Uniprot ID: Q5T2W1

Source protein: Na

Source gene: PDZK1

Class: DEG_SCF_FBW7_1

Location: 477:484

E3 ligase: FBXW7

DEGRON score: 0.9877

ASA_SCORE: 86.025

COIL: 0.9418

CONS_SCORE: 0.2822

DSS_SCORE: 0.5096

HELIX: 0.0346

FCONS_SCORE: 0.8429

RIG_SCORE: 0.6666

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D479G	TCGA-CA-6717	COAD	TCGA	PLDTPPDS	DEG_SCF_FBW7_1	0.6087
p.P477L	SIDM00329	Hodgkin's Lymphoma	GDSC	PLDTPPDS	DEG_SCF_FBW7_1	0.6471
p.P477L	ACH-000806	Lymphoma	CCLE	PLDTPPDS	DEG_SCF_FBW7_1	0.6471
p.P477L	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	PLDTPPDS	DEG_SCF_FBW7_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T2W1	Na	DEG_SCF_FBW7_1	477:484	PLDTPPDS	FBXW7	0.9877	More...
A8MUH7	Putative PDZ domain-containing protein PDZK1P1	DEG_SCF_FBW7_1	360:367	PLDTPPDS	FBXW7	0.9853	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons