DegronMD

Uniprot ID: Q96CX2

Source protein: BTB/POZ domain-containing protein KCTD12

Source gene: KCTD12

Class: DEG_SCF_FBW7_1

Location: 193:200

E3 ligase: FBXW7

DEGRON score: 0.8593

ASA_SCORE: 53.5125

COIL: 0.664

CONS_SCORE: 0.3368

DSS_SCORE: 0.6077

HELIX: 0.1495

FCONS_SCORE: 0.7855

RIG_SCORE: 0.6801

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R184H	TCGA-K4-A5RJ	BLCA	TCGA	PLLTPSQS	DEG_SCF_FBW7_1	0.0833
p.R184H	DO49784	BLCA	ICGC	PLLTPSQS	DEG_SCF_FBW7_1	0.0833
p.D202E	DO229046	LICA	ICGC	PLLTPSQS	DEG_SCF_FBW7_1	0.2778
p.P193R	DO229135	LMS	ICGC	PLLTPSQS	DEG_SCF_FBW7_1	0.7512
p.A191V	DO229224	THCA	ICGC	PLLTPSQS	DEG_SCF_FBW7_1	0.2778
p.R206L	DO229248	THCA	ICGC	PLLTPSQS	DEG_SCF_FBW7_1	0.1667
p.T196A	DO229250	THCA	ICGC	PLLTPSQS	DEG_SCF_FBW7_1	0.825
p.S204N	DO230449	UTCA	ICGC	PLLTPSQS	DEG_SCF_FBW7_1	0.6667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96CX2	BTB/POZ domain-containing protein KCTD12	DEG_SCF_FBW7_1	193:200	PLLTPSQS	FBXW7	0.8593	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons