DegronMD

Uniprot ID: P78368

Source protein: Casein kinase I isoform gamma-2

Source gene: CSNK1G2

Class: DEG_SCF_FBW7_1

Location: 333:340

E3 ligase: FBXW7

DEGRON score: 0.9886

ASA_SCORE: 82.175

COIL: 0.9433

CONS_SCORE: 0.4368

DSS_SCORE: 0.4385

HELIX: 0.0186

FCONS_SCORE: 0.9769

RIG_SCORE: 0.7021

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V341I	TCGA-B5-A11U	UCEC	TCGA	PLPTPIGT	DEG_SCF_FBW7_1	0.3056
p.V341I	DO40804	UCEC	ICGC	PLPTPIGT	DEG_SCF_FBW7_1	0.3056
p.Y327H	TCGA-DI-A1BU	UCEC	TCGA	PLPTPIGT	DEG_SCF_FBW7_1	0.1667
p.Y327H	DO42023	UCEC	ICGC	PLPTPIGT	DEG_SCF_FBW7_1	0.1667
p.H342Y	DO222731	MELA	ICGC	PLPTPIGT	DEG_SCF_FBW7_1	0.2778
p.T343I	ACH-000941	Endometrial/Uterine Cancer	CCLE	PLPTPIGT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78368	Casein kinase I isoform gamma-2	DEG_SCF_FBW7_1	333:340	PLPTPIGT	FBXW7	0.9886	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons