DegronMD

Uniprot ID: Q99575

Source protein: Ribonucleases P/MRP protein subunit POP1

Source gene: POP1

Class: DEG_SCF_FBW7_2

Location: 362:369

E3 ligase: FBXW7

DEGRON score: 0.8862

ASA_SCORE: 73.35

COIL: 0.8186

CONS_SCORE: 0.1746

DSS_SCORE: 0.5138

HELIX: 0.0987

FCONS_SCORE: 0.9897

RIG_SCORE: 0.6568

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A360S	TCGA-43-2578	LUSC	TCGA	PLPTPSQE	DEG_SCF_FBW7_2	0.2778
p.A360S	DO26662	LUSC	ICGC	PLPTPSQE	DEG_SCF_FBW7_2	0.2778
p.K370T	TCGA-EO-A3B0	UCEC	TCGA	PLPTPSQE	DEG_SCF_FBW7_2	0.3056
p.K370T	DO219773	UCEC	ICGC	PLPTPSQE	DEG_SCF_FBW7_2	0.3056
p.E378K	TCGA-NH-A50T	COAD	TCGA	PLPTPSQE	DEG_SCF_FBW7_2	0.0833
p.E378K	DO44086	COAD	ICGC	PLPTPSQE	DEG_SCF_FBW7_2	0.0833
p.K354N	TCGA-VQ-A8P2	STAD	TCGA	PLPTPSQE	DEG_SCF_FBW7_2	0.2222
p.K354N	DO51761	STAD	ICGC	PLPTPSQE	DEG_SCF_FBW7_2	0.2222
p.A360T	DO233760	GACA	ICGC	PLPTPSQE	DEG_SCF_FBW7_2	0.2778
p.A360T	DO229055	LICA	ICGC	PLPTPSQE	DEG_SCF_FBW7_2	0.2778
p.L375F	DO229031	LICA	ICGC	PLPTPSQE	DEG_SCF_FBW7_2	0.1667
p.A356T	DO232224	PBCA	ICGC	PLPTPSQE	DEG_SCF_FBW7_2	0.1667
p.T365A	SIDM00857	Melanoma	GDSC	PLPTPSQE	DEG_SCF_FBW7_2	0.825
p.T365A	G-361	skin	COSMIC	PLPTPSQE	DEG_SCF_FBW7_2	0.825
p.E369K	SIDM00562	Breast Carcinoma	GDSC	PLPTPSQE	DEG_SCF_FBW7_2	0.7022
p.E369K	ACH-002163	Breast Cancer	CCLE	PLPTPSQE	DEG_SCF_FBW7_2	0.7022
p.E369K	MRK-nu-1	breast	COSMIC	PLPTPSQE	DEG_SCF_FBW7_2	0.7022
p.P376S	ACH-002287	Colon/Colorectal Cancer	CCLE	PLPTPSQE	DEG_SCF_FBW7_2	0.1389
p.P376S	NCI-H630	large_intestine	COSMIC	PLPTPSQE	DEG_SCF_FBW7_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99575	Ribonucleases P/MRP protein subunit POP1	DEG_SCF_FBW7_2	362:369	PLPTPSQE	FBXW7	0.8862	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons