DegronMD - Q99575(POP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A360S	TCGA-43-2578	LUSC	TCGA	PLPTPSQE	DEG_SCF_FBW7_2	362:369	Mutation rewiring degron network	0.2778
p.A360S	DO26662	LUSC	ICGC	PLPTPSQE	DEG_SCF_FBW7_2	362:369	Mutation rewiring degron network	0.2778
p.K313E	TCGA-AY-6197	COAD	TCGA	PREMLGPVT	DEG_APCC_DBOX_1	301:309	Mutation substituting flanking lysine	0.3333
p.K313E	DO9956	COAD	ICGC	PREMLGPVT	DEG_APCC_DBOX_1	301:309	Mutation substituting flanking lysine	0.3333
p.P318Q	TCGA-BR-4188	STAD	TCGA	PREMLGPVT	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.0833
p.P318Q	DO38312	STAD	ICGC	PREMLGPVT	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.0833
p.S291N	TCGA-BS-A0UV	UCEC	TCGA	PREMLGPVT	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.0556
p.S291N	DO42793	UCEC	ICGC	PREMLGPVT	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.0556
p.L292F	TCGA-EE-A2GR	SKCM	TCGA	PREMLGPVT	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.0833
p.L292F	DO37996	SKCM	ICGC	PREMLGPVT	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.0833
p.K370T	TCGA-EO-A3B0	UCEC	TCGA	PLPTPSQE	DEG_SCF_FBW7_2	362:369	Mutation rewiring degron network	0.3056
p.K370T	DO219773	UCEC	ICGC	PLPTPSQE	DEG_SCF_FBW7_2	362:369	Mutation rewiring degron network	0.3056
p.Y300H	TCGA-F7-A624	HNSC	TCGA	PREMLGPVT	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.3056
p.Y300H	DO44440	HNSC	ICGC	PREMLGPVT	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.3056
p.S314F	TCGA-GN-A266	SKCM	TCGA	PREMLGPVT	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.1944
p.S314F	TCGA-YD-A89C	SKCM	TCGA	PREMLGPVT	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.1944
p.S314F	DO37432	SKCM	ICGC	PREMLGPVT	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.1944
p.S314F	DO219501	SKCM	ICGC	PREMLGPVT	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.1944
p.E378K	TCGA-NH-A50T	COAD	TCGA	PLPTPSQE	DEG_SCF_FBW7_2	362:369	Mutation rewiring degron network	0.0833
p.E378K	DO44086	COAD	ICGC	PLPTPSQE	DEG_SCF_FBW7_2	362:369	Mutation rewiring degron network	0.0833
p.R296Q	TCGA-VQ-A8P2	STAD	TCGA	PREMLGPVT	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.1944
p.R296Q	DO51761	STAD	ICGC	PREMLGPVT	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.1944
p.K354N	TCGA-VQ-A8P2	STAD	TCGA	PLPTPSQE	DEG_SCF_FBW7_2	362:369	Mutation substituting flanking lysine	0.2222
p.K354N	DO51761	STAD	ICGC	PLPTPSQE	DEG_SCF_FBW7_2	362:369	Mutation substituting flanking lysine	0.2222
p.P301S	TCGA-YD-A9TA	SKCM	TCGA	PREMLGPVT	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.5641
p.P301S	DO219503	SKCM	ICGC	PREMLGPVT	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.5641
p.A360T	DO233760	GACA	ICGC	PLPTPSQE	DEG_SCF_FBW7_2	362:369	Mutation rewiring degron network	0.2778
p.A360T	DO229055	LICA	ICGC	PLPTPSQE	DEG_SCF_FBW7_2	362:369	Mutation rewiring degron network	0.2778
p.G306V	DO229015	LICA	ICGC	PREMLGPVT	DEG_APCC_DBOX_1	301:309	Mutation altering degron motif	0.6421
p.L375F	DO229031	LICA	ICGC	PLPTPSQE	DEG_SCF_FBW7_2	362:369	Mutation rewiring degron network	0.1667
p.G319C	DO229035	LICA	ICGC	PREMLGPVT	DEG_APCC_DBOX_1	301:309	Mutation rewiring degron network	0.0556
p.K313N	DO229037	LICA	ICGC	PREMLGPVT	DEG_APCC_DBOX_1	301:309	Mutation substituting flanking lysine	0.3333
p.A356T	DO232224	PBCA	ICGC	PLPTPSQE	DEG_SCF_FBW7_2	362:369	Mutation rewiring degron network	0.1667
p.T365A	SIDM00857	Melanoma	GDSC	PLPTPSQE	DEG_SCF_FBW7_2	362:369	Mutation altering degron motif	0.825
p.T365A	G-361	skin	COSMIC	PLPTPSQE	DEG_SCF_FBW7_2	362:369	Mutation altering degron motif	0.825
p.E369K	SIDM00562	Breast Carcinoma	GDSC	PLPTPSQE	DEG_SCF_FBW7_2	362:369	Mutation altering degron motif	0.7022
p.E369K	ACH-002163	Breast Cancer	CCLE	PLPTPSQE	DEG_SCF_FBW7_2	362:369	Mutation altering degron motif	0.7022
p.E369K	MRK-nu-1	breast	COSMIC	PLPTPSQE	DEG_SCF_FBW7_2	362:369	Mutation altering degron motif	0.7022
p.P376S	ACH-002287	Colon/Colorectal Cancer	CCLE	PLPTPSQE	DEG_SCF_FBW7_2	362:369	Mutation rewiring degron network	0.1389
p.P376S	NCI-H630	large intestine	COSMIC	PLPTPSQE	DEG_SCF_FBW7_2	362:369	Mutation rewiring degron network	0.1389

Kaplan plot for POP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

POP1

UniProt ID: Q99575

Entrez ID: 10940

Protein name: Ribonucleases P/MRP protein subunit POP1 (hPOP1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for POP1 in