DegronMD

Uniprot ID: Q99575

Source protein: Ribonucleases P/MRP protein subunit POP1

Source gene: POP1

Class: DEG_APCC_DBOX_1

Location: 301:309

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6006

ASA_SCORE: 28.9444

COIL: 0.4749

CONS_SCORE: 0.3802

DSS_SCORE: 0.1676

HELIX: 0.0162

FCONS_SCORE: 1.3409

RIG_SCORE: 0.8092

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K313E	TCGA-AY-6197	COAD	TCGA	PREMLGPVT	DEG_APCC_DBOX_1	0.3333
p.K313E	DO9956	COAD	ICGC	PREMLGPVT	DEG_APCC_DBOX_1	0.3333
p.P318Q	TCGA-BR-4188	STAD	TCGA	PREMLGPVT	DEG_APCC_DBOX_1	0.0833
p.P318Q	DO38312	STAD	ICGC	PREMLGPVT	DEG_APCC_DBOX_1	0.0833
p.S291N	TCGA-BS-A0UV	UCEC	TCGA	PREMLGPVT	DEG_APCC_DBOX_1	0.0556
p.S291N	DO42793	UCEC	ICGC	PREMLGPVT	DEG_APCC_DBOX_1	0.0556
p.L292F	TCGA-EE-A2GR	SKCM	TCGA	PREMLGPVT	DEG_APCC_DBOX_1	0.0833
p.L292F	DO37996	SKCM	ICGC	PREMLGPVT	DEG_APCC_DBOX_1	0.0833
p.Y300H	TCGA-F7-A624	HNSC	TCGA	PREMLGPVT	DEG_APCC_DBOX_1	0.3056
p.Y300H	DO44440	HNSC	ICGC	PREMLGPVT	DEG_APCC_DBOX_1	0.3056
p.S314F	TCGA-GN-A266	SKCM	TCGA	PREMLGPVT	DEG_APCC_DBOX_1	0.1944
p.S314F	TCGA-YD-A89C	SKCM	TCGA	PREMLGPVT	DEG_APCC_DBOX_1	0.1944
p.S314F	DO37432	SKCM	ICGC	PREMLGPVT	DEG_APCC_DBOX_1	0.1944
p.S314F	DO219501	SKCM	ICGC	PREMLGPVT	DEG_APCC_DBOX_1	0.1944
p.R296Q	TCGA-VQ-A8P2	STAD	TCGA	PREMLGPVT	DEG_APCC_DBOX_1	0.1944
p.R296Q	DO51761	STAD	ICGC	PREMLGPVT	DEG_APCC_DBOX_1	0.1944
p.P301S	TCGA-YD-A9TA	SKCM	TCGA	PREMLGPVT	DEG_APCC_DBOX_1	0.5641
p.P301S	DO219503	SKCM	ICGC	PREMLGPVT	DEG_APCC_DBOX_1	0.5641
p.G306V	DO229015	LICA	ICGC	PREMLGPVT	DEG_APCC_DBOX_1	0.6421
p.G319C	DO229035	LICA	ICGC	PREMLGPVT	DEG_APCC_DBOX_1	0.0556
p.K313N	DO229037	LICA	ICGC	PREMLGPVT	DEG_APCC_DBOX_1	0.3333

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99575	Ribonucleases P/MRP protein subunit POP1	DEG_APCC_DBOX_1	301:309	PREMLGPVT	APC,CDC20,FZR1	0.6006	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons