DegronMD

Uniprot ID: Q6P4F1

Source protein: Alpha-

Source gene: FUT10

Class: DEG_SCF_FBW7_1

Location: 430:437

E3 ligase: FBXW7

DEGRON score: 0.6722

ASA_SCORE: 81.3125

COIL: 0.8878

CONS_SCORE: 0.4846

DSS_SCORE: 0.2958

HELIX: 0.0694

FCONS_SCORE: 0.9854

RIG_SCORE: 0.729

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R432L	TCGA-09-2044	OV	TCGA	PLRTPPLS	DEG_SCF_FBW7_1	0.7316
p.R440L	TCGA-66-2800	LUSC	TCGA	PLRTPPLS	DEG_SCF_FBW7_1	0.25
p.R432W	TCGA-D7-8576	STAD	TCGA	PLRTPPLS	DEG_SCF_FBW7_1	0.7523
p.S440L	DO219061	BLCA	ICGC	PLRTPPLS	DEG_SCF_FBW7_1	0.25
p.A428V	DO23224	LINC	ICGC	PLRTPPLS	DEG_SCF_FBW7_1	0.2778
p.R435M	DO45311	LUAD	ICGC	PLRTPPLS	DEG_SCF_FBW7_1	0.8632
p.R435S	DO45311	LUAD	ICGC	PLRTPPLS	DEG_SCF_FBW7_1	0.7427
p.R435K	DO51276	SKCM	ICGC	PLRTPPLS	DEG_SCF_FBW7_1	0.7237
p.F444L	DO41133	UCEC	ICGC	PLRTPPLS	DEG_SCF_FBW7_1	0.1389
p.S445C	SIDM01220	Glioma	GDSC	PLRTPPLS	DEG_SCF_FBW7_1	0.1111
p.S445C	LNZTA3WT4	central_nervous_system	COSMIC	PLRTPPLS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P4F1	Alpha-	DEG_SCF_FBW7_1	430:437	PLRTPPLS	FBXW7	0.6722	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons