DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PLSTPDIS
Uniprot ID:
Q9P2B7
Source protein:
Cilia- and flagella-associated protein 97
Source gene:
CFAP97
Class:
DEG_SCF_FBW7_1
Location:
257:264
E3 ligase:
FBXW7
DEGRON score:
0.9942
ASA_SCORE:
70.575
COIL:
0.9115
CONS_SCORE:
0.5692
DSS_SCORE:
0.5481
HELIX:
0.0396
FCONS_SCORE:
1.2811
RIG_SCORE:
0.7108
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CFAP97 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PLSTPDIS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9P2B7
Cilia- and flagella-associated protein 97
DEG_SCF_FBW7_1
257:264
PLSTPDIS
FBXW7
0.9942
More...