DegronMD

Uniprot ID: Q14289

Source protein: Protein-tyrosine kinase 2-beta

Source gene: PTK2B

Class: DEG_SCF_FBW7_2

Location: 840:846

E3 ligase: FBXW7

DEGRON score: 0.9958

ASA_SCORE: 104.6143

COIL: 0.914

CONS_SCORE: 0.4603

DSS_SCORE: 0.5246

HELIX: 0.0633

FCONS_SCORE: 1.0779

RIG_SCORE: 0.6945

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M832T	TCGA-B5-A3FA	UCEC	TCGA	PLTPEKE	DEG_SCF_FBW7_2	0.1111
p.G854W	TCGA-DF-A2KN	UCEC	TCGA	PLTPEKE	DEG_SCF_FBW7_2	0.1111
p.G854W	DO223282	UCEC	ICGC	PLTPEKE	DEG_SCF_FBW7_2	0.1111
p.E846D	TCGA-EE-A17Z	SKCM	TCGA	PLTPEKE	DEG_SCF_FBW7_2	0.6758
p.F852L	DO10172	COAD	ICGC	PLTPEKE	DEG_SCF_FBW7_2	0.1667
p.R847W	DO15671	HNSC	ICGC	PLTPEKE	DEG_SCF_FBW7_2	0.3056
p.R847W	DO228138	PBCA	ICGC	PLTPEKE	DEG_SCF_FBW7_2	0.3056
p.V833F	DO232842	NACA	ICGC	PLTPEKE	DEG_SCF_FBW7_2	0.1389
p.A848V	DO37667	SKCM	ICGC	PLTPEKE	DEG_SCF_FBW7_2	0.2778
p.A848S	DO37703	SKCM	ICGC	PLTPEKE	DEG_SCF_FBW7_2	0.2778
p.E851K	DO50118	STAD	ICGC	PLTPEKE	DEG_SCF_FBW7_2	0.1944
p.K853N	DO219773	UCEC	ICGC	PLTPEKE	DEG_SCF_FBW7_2	0.5833
p.T842M	SIDM00578	Neuroblastoma	GDSC	PLTPEKE	DEG_SCF_FBW7_2	0.8534
p.T842M	NB1	autonomic_ganglia	COSMIC	PLTPEKE	DEG_SCF_FBW7_2	0.8534
p.N841S	SUP-B15	haematopoietic_and_lymphoid_tissue	COSMIC	PLTPEKE	DEG_SCF_FBW7_2	0.7069
p.N841S	H3255	lung	COSMIC	PLTPEKE	DEG_SCF_FBW7_2	0.7069
p.M843L	DU-145	prostate	COSMIC	PLTPEKE	DEG_SCF_FBW7_2	0.711

Drug responses associated with PTK2B mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00592	HNSC\|head_and_neck	p.G414E (No)	GDSC	PF-562271	2.7412
SIDM00578	NB\|neuroblastoma	p.T842M (Yes)	GDSC	PF-562271	2.7645
SIDM00629	BRCA\|breast	p.C395Y (No)	GDSC	PF-562271	33.971
SIDM00179	SKCM\|melanoma	p.R548K (No)	GDSC	PF-562271	4.5636
SIDM00683	PRAD\|prostate	p.N772K (No)	GDSC	PF-562271	15.8783
SIDM00353	UNCLASSIFIED\|ovary	p.V608A (No)	GDSC	PF-562271	11.2894
SIDM01034	UNCLASSIFIED\|B_cell_leukemia	p.T708I (No)	GDSC	PF-562271	2.6191
SIDM00909	SKCM\|melanoma	p.G562R (No)	GDSC	PF-562271	0.9657
SIDM00139	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.G636R (No)	GDSC	PF-562271	5.1007
SIDM00622	GBM\|glioma	p.F201L (No)	GDSC	PF-562271	5.521
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.A167T (No)	GDSC	PF-562271	6.0635
SIDM00521	SCLC\|lung_small_cell_carcinoma	p.A799S (No)	GDSC	PF-562271	53.0955
SIDM00294	SCLC\|lung_small_cell_carcinoma	p.R936L (No)	GDSC	PF-562271	1.6285
SIDM01045	UCEC\|endometrium	p.E101G (No)	GDSC	PF-562271	24.6526
SIDM01045	UCEC\|endometrium	p.N259S (No)	GDSC	PF-562271	24.6526
SIDM00333	UCEC\|endometrium	p.R572W (No)	GDSC	PF-562271	2.2974
SIDM00249	ESCA\|oesophagus	p.K956T (No)	GDSC	PF-562271	3.4476
SIDM00854	UNCLASSIFIED\|Burkitt_lymphoma	p.A951P (No)	GDSC	PF-562271	1.3827
SIDM00783	COREAD\|large_intestine	p.V637fs*22 (No)	GDSC	PF-562271	1.5455
SIDM00910	NB\|neuroblastoma	p.Q359E (No)	GDSC	PF-562271	1.2267
SIDM00596	UCEC\|endometrium	p.R643W (No)	GDSC	PF-562271	7.126
SIDM00596	UCEC\|endometrium	p.L946F (No)	GDSC	PF-562271	7.126
SIDM00613	LGG\|glioma	p.P645S (No)	GDSC	PF-562271	15.3412
SIDM01057	LAML\|acute_myeloid_leukaemia	p.T978M (No)	GDSC	PF-562271	5.6969
SIDM00888	MB\|medulloblastoma	p.P724S (No)	GDSC	PF-562271	8.145
SIDM01176	ALL\|lymphoblastic_leukemia	p.N883S (No)	GDSC	PF-562271	2.9346
SIDM00486	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.R671fs*165 (No)	GDSC	PF-562271	6.2587
SIDM00321	UNCLASSIFIED\|ovary	p.T409P (No)	GDSC	PF-562271	8.3336
SIDM00973	SKCM\|melanoma	p.K801M (No)	GDSC	PF-562271	3.3005
SIDM00201	UNCLASSIFIED\|ewings_sarcoma	p.V456I (No)	GDSC	PF-562271	2.9613
SIDM01145	STAD\|stomach	p.A294T (No)	GDSC	PF-562271	41.0491
SIDM00810	UNCLASSIFIED\|lung_NSCLC_not_specified	p.R18L (No)	GDSC	PF-562271	5.833
SIDM01205	DLBC\|B_cell_lymphoma	p.S9I (No)	GDSC	PF-562271	2.7667
SIDM00487	COREAD\|large_intestine	p.E496G (No)	GDSC	PF-562271	14.8394
SIDM00963	BRCA\|breast	p.S336L (No)	GDSC	PF-562271	58.7529
SIDM01008	DLBC\|B_cell_lymphoma	p.T4A (No)	GDSC	PF-562271	7.9999
SIDM00343	GBM\|glioma	p.R10Q (No)	GDSC	PF-562271	55.0879
SIDM00542	GBM\|glioma	p.R373L (No)	GDSC	PF-562271	25.2118
SIDM00120	PRAD\|prostate	p.M885L (No)	GDSC	PF-562271	1.8752
SIDM00541	COREAD\|large_intestine	p.E577K (No)	GDSC	PF-562271	23.6187
SIDM00046	LUAD\|lung_NSCLC_adenocarcinoma	p.N883S (No)	GDSC	PF-562271	7.4682
SIDM00230	SCLC\|lung_small_cell_carcinoma	p.G2R (No)	GDSC	PF-562271	13.0143
SIDM01259	ALL\|lymphoblastic_leukemia	p.V613M (No)	GDSC	PF-562271	12.1157
SIDM00291	SKCM\|melanoma	p.Y440D (No)	GDSC	PF-562271	4.7855
SIDM01146	STAD\|stomach	p.A294T (No)	GDSC	PF-562271	8.2826
SIDM00118	COREAD\|large_intestine	p.I807T (No)	GDSC	PF-562271	3.5879

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLTPEKE

Degron related mutations and impact score

Drug responses associated with PTK2B mutations

All proteins holding degron of PLTPEKE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14289	Protein-tyrosine kinase 2-beta	DEG_SCF_FBW7_2	840:846	PLTPEKE	FBXW7	0.9958	More...