DegronMD

Uniprot ID: O75553

Source protein: Disabled homolog 1

Source gene: DAB1

Class: DEG_SCF_FBW7_1

Location: 416:422

E3 ligase: FBXW7

DEGRON score: 0.9912

ASA_SCORE: 76.1

COIL: 0.9383

CONS_SCORE: 0.4586

DSS_SCORE: 0.558

HELIX: 0.0221

FCONS_SCORE: 0.9606

RIG_SCORE: 0.6893

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P423S	TCGA-3N-A9WD	SKCM	TCGA	PLTPLAT	DEG_SCF_FBW7_1	0.3056
p.Q419K	TCGA-91-6829	LUAD	TCGA	PLTPLAT	DEG_SCF_FBW7_1	0.6944
p.R429H	TCGA-A6-6781	COAD	TCGA	PLTPLAT	DEG_SCF_FBW7_1	0.1389
p.R429H	TCGA-CM-6171	COAD	TCGA	PLTPLAT	DEG_SCF_FBW7_1	0.1389
p.P424L	TCGA-AA-3695	COAD	TCGA	PLTPLAT	DEG_SCF_FBW7_1	0.2778
p.P424L	TCGA-F7-A624	HNSC	TCGA	PLTPLAT	DEG_SCF_FBW7_1	0.2778
p.P424L	SIDM00217	Colorectal Carcinoma	GDSC	PLTPLAT	DEG_SCF_FBW7_1	0.2778
p.P424L	ACH-000999	Colon/Colorectal Cancer	CCLE	PLTPLAT	DEG_SCF_FBW7_1	0.2778
p.P424L	SNU-1040	large_intestine	COSMIC	PLTPLAT	DEG_SCF_FBW7_1	0.2778
p.T414M	TCGA-BR-A4QL	STAD	TCGA	PLTPLAT	DEG_SCF_FBW7_1	0.2778
p.Q419H	TCGA-CF-A1HS	BLCA	TCGA	PLTPLAT	DEG_SCF_FBW7_1	0.7582
p.D417N	TCGA-D3-A8GI	SKCM	TCGA	PLTPLAT	DEG_SCF_FBW7_1	0.6932
p.D417N	TCGA-DA-A3F8	SKCM	TCGA	PLTPLAT	DEG_SCF_FBW7_1	0.6932
p.D417N	TCGA-EE-A2GI	SKCM	TCGA	PLTPLAT	DEG_SCF_FBW7_1	0.6932
p.M410I	TCGA-EB-A6QY	SKCM	TCGA	PLTPLAT	DEG_SCF_FBW7_1	0.1667
p.M410I	TCGA-EE-A29D	SKCM	TCGA	PLTPLAT	DEG_SCF_FBW7_1	0.1667
p.M410I	SIDM00591	Oral Cavity Carcinoma	GDSC	PLTPLAT	DEG_SCF_FBW7_1	0.1667
p.M410I	ACH-002045	Head and Neck Cancer	CCLE	PLTPLAT	DEG_SCF_FBW7_1	0.1667
p.M410I	HO-1-u-1	upper_aerodigestive_tract	COSMIC	PLTPLAT	DEG_SCF_FBW7_1	0.1667
p.E425D	DO9346	COAD	ICGC	PLTPLAT	DEG_SCF_FBW7_1	0.25
p.S429R	DO50348	ESAD	ICGC	PLTPLAT	DEG_SCF_FBW7_1	0.1389
p.S431N	DO229177	LMS	ICGC	PLTPLAT	DEG_SCF_FBW7_1	0.0833
p.P406A	DO25396	LUAD	ICGC	PLTPLAT	DEG_SCF_FBW7_1	0.0556
p.FE427LK	DO222702	MELA	ICGC	PLTPLAT	DEG_SCF_FBW7_1	0
p.D421Y	DO31664	OV	ICGC	PLTPLAT	DEG_SCF_FBW7_1	0.7325
p.S429N	DO51510	PACA	ICGC	PLTPLAT	DEG_SCF_FBW7_1	0.1389
p.E428Q	DO36386	READ	ICGC	PLTPLAT	DEG_SCF_FBW7_1	0.1667
p.E428G	DO220273	SARC	ICGC	PLTPLAT	DEG_SCF_FBW7_1	0.1667
p.P430S	DO218849	SKCA	ICGC	PLTPLAT	DEG_SCF_FBW7_1	0.1111
p.D421N	DO37412	SKCM	ICGC	PLTPLAT	DEG_SCF_FBW7_1	0.6932
p.S407F	DO37966	SKCM	ICGC	PLTPLAT	DEG_SCF_FBW7_1	0.0833
p.S407F	DO51234	SKCM	ICGC	PLTPLAT	DEG_SCF_FBW7_1	0.0833
p.P430L	DO51276	SKCM	ICGC	PLTPLAT	DEG_SCF_FBW7_1	0.1111
p.S409L	DO51254	SKCM	ICGC	PLTPLAT	DEG_SCF_FBW7_1	0.1389
p.D416N	DO219481	SKCM	ICGC	PLTPLAT	DEG_SCF_FBW7_1	0.6932
p.P417S	DO219466	SKCM	ICGC	PLTPLAT	DEG_SCF_FBW7_1	0.6752
p.A414T	DO223286	UCEC	ICGC	PLTPLAT	DEG_SCF_FBW7_1	0.2778
p.S412F	DO43186	UCEC	ICGC	PLTPLAT	DEG_SCF_FBW7_1	0.2222
p.R429C	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PLTPLAT	DEG_SCF_FBW7_1	0.1389
p.R429C	ACH-000953	Leukemia	CCLE	PLTPLAT	DEG_SCF_FBW7_1	0.1389
p.R429C	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PLTPLAT	DEG_SCF_FBW7_1	0.1389
p.A411S	ACH-000795	Leukemia	CCLE	PLTPLAT	DEG_SCF_FBW7_1	0.1944
p.A411T	CAL-29	urinary_tract	COSMIC	PLTPLAT	DEG_SCF_FBW7_1	0.1944
p.T426M	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	PLTPLAT	DEG_SCF_FBW7_1	0.2222
p.A411V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PLTPLAT	DEG_SCF_FBW7_1	0.1944
p.P422L	SNU-1040	large_intestine	COSMIC	PLTPLAT	DEG_SCF_FBW7_1	0.7582
p.R427C	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PLTPLAT	DEG_SCF_FBW7_1	0.1944
p.T422A	IST-MES1	pleura	COSMIC	PLTPLAT	DEG_SCF_FBW7_1	0.7139
p.M408I	HO-1-u-1	upper_aerodigestive_tract	COSMIC	PLTPLAT	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLTPLAT

Degron related mutations and impact score

Drug responses associated with DAB1 mutations

All proteins holding degron of PLTPLAT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75553	Disabled homolog 1	DEG_SCF_FBW7_1	416:422	PLTPLAT	FBXW7	0.9912	More...