DegronMD

Uniprot ID: Q9NPC6

Source protein: Myozenin-2

Source gene: MYOZ2

Class: DEG_SCF_FBW7_1

Location: 105:111

E3 ligase: FBXW7

DEGRON score: 0.9494

ASA_SCORE: 87.7571

COIL: 0.9366

CONS_SCORE: 0.6523

DSS_SCORE: 0.8879

HELIX: 0.0109

FCONS_SCORE: 0.9761

RIG_SCORE: 0.5353

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A104S	TCGA-AA-3966	COAD	TCGA	PLTPPNT	DEG_SCF_FBW7_1	0.3056
p.A104S	DO10068	COAD	ICGC	PLTPPNT	DEG_SCF_FBW7_1	0.3056
p.P109S	TCGA-D3-A3MR	SKCM	TCGA	PLTPPNT	DEG_SCF_FBW7_1	0.5641
p.P109S	DO47256	SKCM	ICGC	PLTPPNT	DEG_SCF_FBW7_1	0.5641
p.S101T	TCGA-DD-AAW2	LIHC	TCGA	PLTPPNT	DEG_SCF_FBW7_1	0.2222
p.S101T	DO52288	LIHC	ICGC	PLTPPNT	DEG_SCF_FBW7_1	0.2222
p.S101L	TCGA-EE-A29D	SKCM	TCGA	PLTPPNT	DEG_SCF_FBW7_1	0.2222
p.S101L	TCGA-FW-A3R5	SKCM	TCGA	PLTPPNT	DEG_SCF_FBW7_1	0.2222
p.S101L	DO37406	SKCM	ICGC	PLTPPNT	DEG_SCF_FBW7_1	0.2222
p.S101L	DO38123	SKCM	ICGC	PLTPPNT	DEG_SCF_FBW7_1	0.2222
p.S101L	SIDM00392	Melanoma	GDSC	PLTPPNT	DEG_SCF_FBW7_1	0.2222
p.S101L	ACH-000810	Skin Cancer	CCLE	PLTPPNT	DEG_SCF_FBW7_1	0.2222
p.S101L	SK-MEL-30	skin	COSMIC	PLTPPNT	DEG_SCF_FBW7_1	0.2222
p.S95N	DO227970	COCA	ICGC	PLTPPNT	DEG_SCF_FBW7_1	0.0556
p.N119H	SIDM01588	Endometrial Carcinoma	GDSC	PLTPPNT	DEG_SCF_FBW7_1	0.1111
p.N119H	ACH-000993	Endometrial/Uterine Cancer	CCLE	PLTPPNT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NPC6	Myozenin-2	DEG_SCF_FBW7_1	105:111	PLTPPNT	FBXW7	0.9494	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons