DegronMD

Uniprot ID: P46821

Source protein: Microtubule-associated protein 1B

Source gene: MAP1B

Class: DEG_SCF_FBW7_1

Location: 1786:1792

E3 ligase: FBXW7

DEGRON score: 0.9966

ASA_SCORE: 105.5857

COIL: 0.9576

CONS_SCORE: 0.5276

DSS_SCORE: 0.5841

HELIX: 0.019

FCONS_SCORE: 1.0488

RIG_SCORE: 0.6382

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1792P	TCGA-AA-3966	COAD	TCGA	PLTPRES	DEG_SCF_FBW7_1	0.7863
p.S1792P	DO10068	COAD	ICGC	PLTPRES	DEG_SCF_FBW7_1	0.7863
p.E1776D	TCGA-BK-A6W3	UCEC	TCGA	PLTPRES	DEG_SCF_FBW7_1	0.0556
p.E1776D	DO50076	UCEC	ICGC	PLTPRES	DEG_SCF_FBW7_1	0.0556
p.S1801L	TCGA-CV-7406	HNSC	TCGA	PLTPRES	DEG_SCF_FBW7_1	0.5278
p.S1801L	DO15422	HNSC	ICGC	PLTPRES	DEG_SCF_FBW7_1	0.5278
p.S1801L	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PLTPRES	DEG_SCF_FBW7_1	0.5278
p.S1801L	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PLTPRES	DEG_SCF_FBW7_1	0.5278
p.P1780L	TCGA-EE-A20C	SKCM	TCGA	PLTPRES	DEG_SCF_FBW7_1	0.1667
p.P1780L	DO222775	MELA	ICGC	PLTPRES	DEG_SCF_FBW7_1	0.1667
p.P1780L	DO47665	SKCM	ICGC	PLTPRES	DEG_SCF_FBW7_1	0.1667
p.P1786S	TCGA-EE-A2MG	SKCM	TCGA	PLTPRES	DEG_SCF_FBW7_1	0.6752
p.P1786S	DO37421	SKCM	ICGC	PLTPRES	DEG_SCF_FBW7_1	0.6752
p.Y1796H	TCGA-VQ-A8P2	STAD	TCGA	PLTPRES	DEG_SCF_FBW7_1	0.6667
p.Y1796H	DO51761	STAD	ICGC	PLTPRES	DEG_SCF_FBW7_1	0.6667
p.P1789S	DO234199	ESAD	ICGC	PLTPRES	DEG_SCF_FBW7_1	0.6752
p.P1780R	ACH-001395	Breast Cancer	CCLE	PLTPRES	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46821	Microtubule-associated protein 1B	DEG_SCF_FBW7_1	1786:1792	PLTPRES	FBXW7	0.9966	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons