DegronMD

Uniprot ID: Q00975

Source protein: Voltage-dependent N-type calcium channel subunit alpha-1B

Source gene: CACNA1B

Class: DEG_SCF_FBW7_1

Location: 2194:2200

E3 ligase: FBXW7

DEGRON score: 0.9912

ASA_SCORE: 79.6286

COIL: 0.9029

CONS_SCORE: 0.3085

DSS_SCORE: 0.7144

HELIX: 0.0623

FCONS_SCORE: 1.0632

RIG_SCORE: 0.6784

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2184H	TCGA-2J-AABI	PAAD	TCGA	PLTPRPS	DEG_SCF_FBW7_1	0.0556
p.R2198S	TCGA-95-7043	LUAD	TCGA	PLTPRPS	DEG_SCF_FBW7_1	0.6316
p.R2198S	TCGA-FS-A1ZH	SKCM	TCGA	PLTPRPS	DEG_SCF_FBW7_1	0.6316
p.R2198S	TCGA-H2-A26U	THCA	TCGA	PLTPRPS	DEG_SCF_FBW7_1	0.6316
p.R2198H	TCGA-AX-A2HG	UCEC	TCGA	PLTPRPS	DEG_SCF_FBW7_1	0.7133
p.R2198H	TCGA-B5-A11E	UCEC	TCGA	PLTPRPS	DEG_SCF_FBW7_1	0.7133
p.R2198H	TCGA-D5-6927	COAD	TCGA	PLTPRPS	DEG_SCF_FBW7_1	0.7133
p.R2198H	SIDM01274	Esophageal Carcinoma	GDSC	PLTPRPS	DEG_SCF_FBW7_1	0.7133
p.R2198H	SIDM01943	Colorectal Carcinoma	GDSC	PLTPRPS	DEG_SCF_FBW7_1	0.7133
p.P2194S	TCGA-B5-A11E	UCEC	TCGA	PLTPRPS	DEG_SCF_FBW7_1	0.6752
p.G2185S	TCGA-D1-A168	UCEC	TCGA	PLTPRPS	DEG_SCF_FBW7_1	0.0833
p.G2185S	TCGA-HU-A4GX	STAD	TCGA	PLTPRPS	DEG_SCF_FBW7_1	0.0833
p.R2188K	TCGA-ER-A19O	SKCM	TCGA	PLTPRPS	DEG_SCF_FBW7_1	0.1667
p.T2193K	TCGA-G2-AA3F	BLCA	TCGA	PLTPRPS	DEG_SCF_FBW7_1	0.3056
p.P2197L	TCGA-RD-A7C1	STAD	TCGA	PLTPRPS	DEG_SCF_FBW7_1	0.7582
p.T2191K	DO51885	BLCA	ICGC	PLTPRPS	DEG_SCF_FBW7_1	0.25
p.R2196H	DO10332	COAD	ICGC	PLTPRPS	DEG_SCF_FBW7_1	0.8244
p.R2196H	DO33432	PACA	ICGC	PLTPRPS	DEG_SCF_FBW7_1	0.8244
p.R2196H	DO41644	UCEC	ICGC	PLTPRPS	DEG_SCF_FBW7_1	0.8244
p.R2196H	DO41337	UCEC	ICGC	PLTPRPS	DEG_SCF_FBW7_1	0.8244
p.T2209M	DO222866	COCA	ICGC	PLTPRPS	DEG_SCF_FBW7_1	0.0833
p.R2185Q	DO233888	GACA	ICGC	PLTPRPS	DEG_SCF_FBW7_1	0.0833
p.R2196S	DO24739	LUAD	ICGC	PLTPRPS	DEG_SCF_FBW7_1	0.7427
p.R2196S	DO37575	SKCM	ICGC	PLTPRPS	DEG_SCF_FBW7_1	0.7427
p.R2196S	DO40045	THCA	ICGC	PLTPRPS	DEG_SCF_FBW7_1	0.7427
p.R2186K	DO38063	SKCM	ICGC	PLTPRPS	DEG_SCF_FBW7_1	0.1111
p.P2195L	DO50132	STAD	ICGC	PLTPRPS	DEG_SCF_FBW7_1	0.7582
p.P2192S	DO41644	UCEC	ICGC	PLTPRPS	DEG_SCF_FBW7_1	0.2778
p.G2199D	DO42793	UCEC	ICGC	PLTPRPS	DEG_SCF_FBW7_1	0.7198
p.I2209T	DO42665	UCEC	ICGC	PLTPRPS	DEG_SCF_FBW7_1	0.0833
p.S2184T	YAPC	pancreas	COSMIC	PLTPRPS	DEG_SCF_FBW7_1	0.0556
p.S2184T	TALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	PLTPRPS	DEG_SCF_FBW7_1	0.0556
p.S2184T	SCC-3	haematopoietic_and_lymphoid_tissue	COSMIC	PLTPRPS	DEG_SCF_FBW7_1	0.0556
p.S2184T	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	PLTPRPS	DEG_SCF_FBW7_1	0.0556
p.L2194M	NCI-H2342	lung	COSMIC	PLTPRPS	DEG_SCF_FBW7_1	0.711

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLTPRPS

Degron related mutations and impact score

Drug responses associated with CACNA1B mutations

All proteins holding degron of PLTPRPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q00975	Voltage-dependent N-type calcium channel subunit alpha-1B	DEG_SCF_FBW7_1	2194:2200	PLTPRPS	FBXW7	0.9912	More...