DegronMD

Uniprot ID: Q96MM6

Source protein: Heat shock 70 kDa protein 12B

Source gene: HSPA12B

Class: DEG_SCF_FBW7_1

Location: 40:46

E3 ligase: FBXW7

DEGRON score: 0.998

ASA_SCORE: 84.3286

COIL: 0.9269

CONS_SCORE: 0.5666

DSS_SCORE: 0.6716

HELIX: 0.0337

FCONS_SCORE: 1.0309

RIG_SCORE: 0.6213

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G37S	TCGA-2W-A8YY	CESC	TCGA	PLTPSQS	DEG_SCF_FBW7_1	0.25
p.G37S	DO223732	CESC	ICGC	PLTPSQS	DEG_SCF_FBW7_1	0.25
p.R52Q	TCGA-AA-3980	COAD	TCGA	PLTPSQS	DEG_SCF_FBW7_1	0.1667
p.R52Q	DO8455	COAD	ICGC	PLTPSQS	DEG_SCF_FBW7_1	0.1667
p.T32I	TCGA-DA-A1IC	SKCM	TCGA	PLTPSQS	DEG_SCF_FBW7_1	0.1111
p.T32I	DO37430	SKCM	ICGC	PLTPSQS	DEG_SCF_FBW7_1	0.1111
p.S44L	TCGA-E6-A1LX	UCEC	TCGA	PLTPSQS	DEG_SCF_FBW7_1	0.7667
p.S44L	DO41020	UCEC	ICGC	PLTPSQS	DEG_SCF_FBW7_1	0.7667
p.E50K	TCGA-EE-A2MR	SKCM	TCGA	PLTPSQS	DEG_SCF_FBW7_1	0.2222
p.E50K	DO37819	SKCM	ICGC	PLTPSQS	DEG_SCF_FBW7_1	0.2222
p.R52L	TCGA-ER-A2NH	SKCM	TCGA	PLTPSQS	DEG_SCF_FBW7_1	0.1667
p.R52L	DO47683	SKCM	ICGC	PLTPSQS	DEG_SCF_FBW7_1	0.1667
p.L41I	TCGA-EY-A215	UCEC	TCGA	PLTPSQS	DEG_SCF_FBW7_1	0.6063
p.L41I	DO42665	UCEC	ICGC	PLTPSQS	DEG_SCF_FBW7_1	0.6063
p.P54L	DO222753	MELA	ICGC	PLTPSQS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96MM6	Heat shock 70 kDa protein 12B	DEG_SCF_FBW7_1	40:46	PLTPSQS	FBXW7	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons