DegronMD - Q96MM6(HSPA12B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S21F	TCGA-2J-AABP	PAAD	TCGA	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation altering degron motif	0.6871
p.S21F	TCGA-CA-6717	COAD	TCGA	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation altering degron motif	0.6871
p.S21F	TCGA-QC-A7B5	SARC	TCGA	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation altering degron motif	0.6871
p.S21F	DO8264	COAD	ICGC	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation altering degron motif	0.6871
p.S21F	DO51668	PAAD	ICGC	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation altering degron motif	0.6871
p.S21F	DO220239	SARC	ICGC	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation altering degron motif	0.6871
p.G37S	TCGA-2W-A8YY	CESC	TCGA	PLTPSQS	DEG_SCF_FBW7_1	40:46	Mutation rewiring degron network	0.25
p.G37S	DO223732	CESC	ICGC	PLTPSQS	DEG_SCF_FBW7_1	40:46	Mutation rewiring degron network	0.25
p.R52Q	TCGA-AA-3980	COAD	TCGA	PLTPSQS	DEG_SCF_FBW7_1	40:46	Mutation rewiring degron network	0.1667
p.R52Q	DO8455	COAD	ICGC	PLTPSQS	DEG_SCF_FBW7_1	40:46	Mutation rewiring degron network	0.1667
p.P18L	TCGA-B6-A0RT	BRCA	TCGA	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation altering degron motif	0.6471
p.P18L	DO5375	BRCA	ICGC	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation altering degron motif	0.6471
p.P26L	TCGA-BF-AAP2	SKCM	TCGA	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation altering degron motif	0.6471
p.P26L	DO219466	SKCM	ICGC	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation altering degron motif	0.6471
p.T32I	TCGA-DA-A1IC	SKCM	TCGA	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation rewiring degron network	0.1667
p.T32I	TCGA-DA-A1IC	SKCM	TCGA	PLTPSQS	DEG_SCF_FBW7_1	40:46	Mutation rewiring degron network	0.1111
p.T32I	DO37430	SKCM	ICGC	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation rewiring degron network	0.1667
p.T32I	DO37430	SKCM	ICGC	PLTPSQS	DEG_SCF_FBW7_1	40:46	Mutation rewiring degron network	0.1111
p.S44L	TCGA-E6-A1LX	UCEC	TCGA	PLTPSQS	DEG_SCF_FBW7_1	40:46	Mutation altering degron motif	0.7667
p.S44L	DO41020	UCEC	ICGC	PLTPSQS	DEG_SCF_FBW7_1	40:46	Mutation altering degron motif	0.7667
p.P18Q	TCGA-EB-A299	SKCM	TCGA	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation altering degron motif	0.5924
p.P18Q	DO37794	SKCM	ICGC	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation altering degron motif	0.5924
p.E50K	TCGA-EE-A2MR	SKCM	TCGA	PLTPSQS	DEG_SCF_FBW7_1	40:46	Mutation rewiring degron network	0.2222
p.E50K	DO37819	SKCM	ICGC	PLTPSQS	DEG_SCF_FBW7_1	40:46	Mutation rewiring degron network	0.2222
p.E6K	TCGA-ER-A193	SKCM	TCGA	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation rewiring degron network	0.0556
p.E6K	DO47368	SKCM	ICGC	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation rewiring degron network	0.0556
p.R52L	TCGA-ER-A2NH	SKCM	TCGA	PLTPSQS	DEG_SCF_FBW7_1	40:46	Mutation rewiring degron network	0.1667
p.R52L	DO47683	SKCM	ICGC	PLTPSQS	DEG_SCF_FBW7_1	40:46	Mutation rewiring degron network	0.1667
p.L41I	TCGA-EY-A215	UCEC	TCGA	PLTPSQS	DEG_SCF_FBW7_1	40:46	Mutation altering degron motif	0.6063
p.L41I	DO42665	UCEC	ICGC	PLTPSQS	DEG_SCF_FBW7_1	40:46	Mutation altering degron motif	0.6063
p.R20Q	DO234453	ESAD	ICGC	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation altering degron motif	0.6218
p.G28C	DO229019	LICA	ICGC	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation rewiring degron network	0.2778
p.P54L	DO222753	MELA	ICGC	PLTPSQS	DEG_SCF_FBW7_1	40:46	Mutation rewiring degron network	0.1111
p.V23L	SIDM01090	Colorectal Carcinoma	GDSC	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation altering degron motif	0.6765
p.V23L	SIDM00266	Ewing's Sarcoma	GDSC	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation altering degron motif	0.6765
p.V23L	SIDM00878	Breast Carcinoma	GDSC	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation altering degron motif	0.6765
p.V23L	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation altering degron motif	0.6765
p.V23L	SIDM00808	Burkitt's Lymphoma	GDSC	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation altering degron motif	0.6765
p.V23L	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation altering degron motif	0.6765
p.V23L	SIDM01254	Burkitt's Lymphoma	GDSC	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation altering degron motif	0.6765
p.P22Q	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation altering degron motif	0.5924
p.P22Q	ACH-000482	Lung Cancer	CCLE	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation altering degron motif	0.5924
p.P22Q	RERF-LC-KJ	lung	COSMIC	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation altering degron motif	0.5924
p.P18T	SIDM01254	Burkitt's Lymphoma	GDSC	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation altering degron motif	0.5919
p.P18T	ACH-000707	Lymphoma	CCLE	SSPERSPVPSP	DEG_COP1_1	16:26	Mutation altering degron motif	0.5919

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HSPA12B

UniProt ID: Q96MM6

Entrez ID: 116835

Protein name: Heat shock 70 kDa protein 12B

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HSPA12B in