DegronMD

Uniprot ID: Q96MM6

Source protein: Heat shock 70 kDa protein 12B

Source gene: HSPA12B

Class: DEG_COP1_1

Location: 16:26

E3 ligase: COP1

DEGRON score: 0.9873

ASA_SCORE: 88.6

COIL: 0.9618

CONS_SCORE: 0.5914

DSS_SCORE: 0.724

HELIX: 0.0112

FCONS_SCORE: 1.0398

RIG_SCORE: 0.5414

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S21F	TCGA-2J-AABP	PAAD	TCGA	SSPERSPVPSP	DEG_COP1_1	0.6871
p.S21F	TCGA-CA-6717	COAD	TCGA	SSPERSPVPSP	DEG_COP1_1	0.6871
p.S21F	TCGA-QC-A7B5	SARC	TCGA	SSPERSPVPSP	DEG_COP1_1	0.6871
p.S21F	DO8264	COAD	ICGC	SSPERSPVPSP	DEG_COP1_1	0.6871
p.S21F	DO51668	PAAD	ICGC	SSPERSPVPSP	DEG_COP1_1	0.6871
p.S21F	DO220239	SARC	ICGC	SSPERSPVPSP	DEG_COP1_1	0.6871
p.P18L	TCGA-B6-A0RT	BRCA	TCGA	SSPERSPVPSP	DEG_COP1_1	0.6471
p.P18L	DO5375	BRCA	ICGC	SSPERSPVPSP	DEG_COP1_1	0.6471
p.P26L	TCGA-BF-AAP2	SKCM	TCGA	SSPERSPVPSP	DEG_COP1_1	0.6471
p.P26L	DO219466	SKCM	ICGC	SSPERSPVPSP	DEG_COP1_1	0.6471
p.T32I	TCGA-DA-A1IC	SKCM	TCGA	SSPERSPVPSP	DEG_COP1_1	0.1667
p.T32I	DO37430	SKCM	ICGC	SSPERSPVPSP	DEG_COP1_1	0.1667
p.P18Q	TCGA-EB-A299	SKCM	TCGA	SSPERSPVPSP	DEG_COP1_1	0.5924
p.P18Q	DO37794	SKCM	ICGC	SSPERSPVPSP	DEG_COP1_1	0.5924
p.E6K	TCGA-ER-A193	SKCM	TCGA	SSPERSPVPSP	DEG_COP1_1	0.0556
p.E6K	DO47368	SKCM	ICGC	SSPERSPVPSP	DEG_COP1_1	0.0556
p.R20Q	DO234453	ESAD	ICGC	SSPERSPVPSP	DEG_COP1_1	0.6218
p.G28C	DO229019	LICA	ICGC	SSPERSPVPSP	DEG_COP1_1	0.2778
p.V23L	SIDM01090	Colorectal Carcinoma	GDSC	SSPERSPVPSP	DEG_COP1_1	0.6765
p.V23L	SIDM00266	Ewing's Sarcoma	GDSC	SSPERSPVPSP	DEG_COP1_1	0.6765
p.V23L	SIDM00878	Breast Carcinoma	GDSC	SSPERSPVPSP	DEG_COP1_1	0.6765
p.V23L	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	SSPERSPVPSP	DEG_COP1_1	0.6765
p.V23L	SIDM00808	Burkitt's Lymphoma	GDSC	SSPERSPVPSP	DEG_COP1_1	0.6765
p.V23L	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	SSPERSPVPSP	DEG_COP1_1	0.6765
p.V23L	SIDM01254	Burkitt's Lymphoma	GDSC	SSPERSPVPSP	DEG_COP1_1	0.6765
p.P22Q	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	SSPERSPVPSP	DEG_COP1_1	0.5924
p.P22Q	ACH-000482	Lung Cancer	CCLE	SSPERSPVPSP	DEG_COP1_1	0.5924
p.P22Q	RERF-LC-KJ	lung	COSMIC	SSPERSPVPSP	DEG_COP1_1	0.5924
p.P18T	SIDM01254	Burkitt's Lymphoma	GDSC	SSPERSPVPSP	DEG_COP1_1	0.5919
p.P18T	ACH-000707	Lymphoma	CCLE	SSPERSPVPSP	DEG_COP1_1	0.5919

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SSPERSPVPSP

Degron related mutations and impact score

Drug responses associated with HSPA12B mutations

All proteins holding degron of SSPERSPVPSP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96MM6	Heat shock 70 kDa protein 12B	DEG_COP1_1	16:26	SSPERSPVPSP	COP1	0.9873	More...