DegronMD

Uniprot ID: Q5KSL6

Source protein: Diacylglycerol kinase kappa

Source gene: DGKK

Class: DEG_SCF_FBW7_1

Location: 1263:1269

E3 ligase: FBXW7

DEGRON score: 0.6363

ASA_SCORE: 87.2571

COIL: 0.8029

CONS_SCORE: 0.2896

DSS_SCORE: 0.8876

HELIX: 0.1497

FCONS_SCORE: 0.9912

RIG_SCORE: 0.6571

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1258T	SIDM02059	Colorectal Carcinoma	GDSC	PLTPSRS	DEG_SCF_FBW7_1	0.1944
p.S1269Y	SIDM02027	Colorectal Carcinoma	GDSC	PLTPSRS	DEG_SCF_FBW7_1	0.712
p.D1261G	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PLTPSRS	DEG_SCF_FBW7_1	0.2778
p.R1254C	SIDM01611	Endometrial Carcinoma	GDSC	PLTPSRS	DEG_SCF_FBW7_1	0.0833
p.R1254H	SIDM01619	Endometrial Carcinoma	GDSC	PLTPSRS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5KSL6	Diacylglycerol kinase kappa	DEG_SCF_FBW7_1	1263:1269	PLTPSRS	FBXW7	0.6363	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons