DegronMD

Uniprot ID: Q2TAL5

Source protein: Smoothelin-like protein 2

Source gene: SMTNL2

Class: DEG_SCF_FBW7_1

Location: 271:278

E3 ligase: FBXW7

DEGRON score: 0.9612

ASA_SCORE: 98.475

COIL: 0.9705

CONS_SCORE: 0.3732

DSS_SCORE: 0.7386

HELIX: 0.0096

FCONS_SCORE: 0.9341

RIG_SCORE: 0.5716

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A286D	TCGA-AA-A00N	COAD	TCGA	PLVTPPQS	DEG_SCF_FBW7_1	0.1111
p.A286D	DO9876	COAD	ICGC	PLVTPPQS	DEG_SCF_FBW7_1	0.1111
p.S278L	TCGA-CN-4723	HNSC	TCGA	PLVTPPQS	DEG_SCF_FBW7_1	0.8778
p.S278L	DO14830	HNSC	ICGC	PLVTPPQS	DEG_SCF_FBW7_1	0.8778
p.V261M	TCGA-DF-A2KN	UCEC	TCGA	PLVTPPQS	DEG_SCF_FBW7_1	0.0556
p.P270Q	TCGA-ER-A19Q	SKCM	TCGA	PLVTPPQS	DEG_SCF_FBW7_1	0.3056
p.P270Q	DO47497	SKCM	ICGC	PLVTPPQS	DEG_SCF_FBW7_1	0.3056
p.F268C	DO9708	COAD	ICGC	PLVTPPQS	DEG_SCF_FBW7_1	0.25
p.K266N	DO17462	KIRC	ICGC	PLVTPPQS	DEG_SCF_FBW7_1	0.1944
p.E276V	DO47257	SKCM	ICGC	PLVTPPQS	DEG_SCF_FBW7_1	0.7693
p.P284L	SIDM01660	Kidney Carcinoma	GDSC	PLVTPPQS	DEG_SCF_FBW7_1	0.1667
p.V280A	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PLVTPPQS	DEG_SCF_FBW7_1	0.2778
p.V280A	ACH-000942	Leukemia	CCLE	PLVTPPQS	DEG_SCF_FBW7_1	0.2778
p.T262A	JEG-3	placenta	COSMIC	PLVTPPQS	DEG_SCF_FBW7_1	0.0833
p.A275V	NCI-H1155	lung	COSMIC	PLVTPPQS	DEG_SCF_FBW7_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2TAL5	Smoothelin-like protein 2	DEG_SCF_FBW7_1	271:278	PLVTPPQS	FBXW7	0.9612	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons