DegronMD - Q2TAL5(SMTNL2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N246D	TCGA-06-1801	GBM	TCGA	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.25
p.N246D	DO11986	GBM	ICGC	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.25
p.A286D	TCGA-AA-A00N	COAD	TCGA	PLVTPPQS	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.1111
p.A286D	DO9876	COAD	ICGC	PLVTPPQS	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.1111
p.T250M	TCGA-BR-8485	STAD	TCGA	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.1389
p.T250M	DO47823	STAD	ICGC	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.1389
p.T250M	SIDM01617	Endometrial Carcinoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.1389
p.K245N	TCGA-CA-6718	COAD	TCGA	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.2778
p.K245N	SIDM00193	Colorectal Carcinoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.2778
p.K245N	ACH-000991	Colon/Colorectal Cancer	CCLE	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.2778
p.K245N	SNU-81	large intestine	COSMIC	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.2778
p.S278L	TCGA-CN-4723	HNSC	TCGA	PLVTPPQS	DEG_SCF_FBW7_1	271:278	Mutation altering degron motif	0.8778
p.S278L	DO14830	HNSC	ICGC	PLVTPPQS	DEG_SCF_FBW7_1	271:278	Mutation altering degron motif	0.8778
p.E233K	TCGA-D3-A5GO	SKCM	TCGA	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.2222
p.V261M	TCGA-DF-A2KN	UCEC	TCGA	PLVTPPQS	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.0556
p.P270Q	TCGA-ER-A19Q	SKCM	TCGA	PLVTPPQS	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.3056
p.P270Q	DO47497	SKCM	ICGC	PLVTPPQS	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.3056
p.E244D	TCGA-GC-A3RB	BLCA	TCGA	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.3056
p.P240S	TCGA-XF-A8HD	BLCA	TCGA	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation altering degron motif	0.6752
p.S230N	TCGA-ZF-AA4N	BLCA	TCGA	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.1389
p.S230N	DO219082	BLCA	ICGC	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.1389
p.S230N	DO231954	LICA	ICGC	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.1389
p.F268C	DO9708	COAD	ICGC	PLVTPPQS	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.25
p.K266N	DO17462	KIRC	ICGC	PLVTPPQS	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.1944
p.A244S	DO228974	LICA	ICGC	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.3056
p.S235I	DO229029	LICA	ICGC	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.2778
p.E276V	DO47257	SKCM	ICGC	PLVTPPQS	DEG_SCF_FBW7_1	271:278	Mutation altering degron motif	0.7693
p.W251R	SIDM00845	Burkitt's Lymphoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.1111
p.W251R	SIDM01090	Colorectal Carcinoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.1111
p.W251R	SIDM01245	T-Lymphoblastic Leukemia	GDSC	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.1111
p.W251R	SIDM00087	Plasma Cell Myeloma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.1111
p.W251R	SIDM00844	Burkitt's Lymphoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.1111
p.W251R	SIDM00907	Burkitt's Lymphoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.1111
p.W251R	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.1111
p.W251R	SIDM00621	Ewing's Sarcoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.1111
p.W251R	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.1111
p.W251R	SIDM00479	Esophageal Carcinoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.1111
p.W251R	SIDM00991	T-Lymphoblastic Leukemia	GDSC	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.1111
p.E244K	SIDM00445	Esophageal Carcinoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.3056
p.E244K	OACp4C	oesophagus	COSMIC	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.3056
p.E244K	NCI-H187	lung	COSMIC	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.3056
p.T236M	SIDM00251	Gastric Carcinoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.3056
p.T236M	ACH-000949	Gastric Cancer	CCLE	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.3056
p.T236M	TGBC11TKB	stomach	COSMIC	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.3056
p.P284L	SIDM01660	Kidney Carcinoma	GDSC	PLVTPPQS	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.1667
p.V280A	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PLVTPPQS	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.2778
p.V280A	ACH-000942	Leukemia	CCLE	PLVTPPQS	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.2778
p.T262A	JEG-3	placenta	COSMIC	PLVTPPQS	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.0833
p.L229P	MFE-319	endometrium	COSMIC	PWTPSPS	DEG_SCF_FBW7_1	237:243	Mutation rewiring degron network	0.1111
p.A275V	NCI-H1155	lung	COSMIC	PLVTPPQS	DEG_SCF_FBW7_1	271:278	Mutation altering degron motif	0.6936

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMTNL2

UniProt ID: Q2TAL5

Entrez ID: 342527

Protein name: Smoothelin-like protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMTNL2 in