DegronMD

Uniprot ID: Q2TAL5

Source protein: Smoothelin-like protein 2

Source gene: SMTNL2

Class: DEG_SCF_FBW7_1

Location: 237:243

E3 ligase: FBXW7

DEGRON score: 0.9895

ASA_SCORE: 95.7714

COIL: 0.9601

CONS_SCORE: 0.3799

DSS_SCORE: 0.5288

HELIX: 0.0194

FCONS_SCORE: 1.0738

RIG_SCORE: 0.6815

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N246D	TCGA-06-1801	GBM	TCGA	PWTPSPS	DEG_SCF_FBW7_1	0.25
p.N246D	DO11986	GBM	ICGC	PWTPSPS	DEG_SCF_FBW7_1	0.25
p.T250M	TCGA-BR-8485	STAD	TCGA	PWTPSPS	DEG_SCF_FBW7_1	0.1389
p.T250M	DO47823	STAD	ICGC	PWTPSPS	DEG_SCF_FBW7_1	0.1389
p.T250M	SIDM01617	Endometrial Carcinoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.1389
p.K245N	TCGA-CA-6718	COAD	TCGA	PWTPSPS	DEG_SCF_FBW7_1	0.2778
p.K245N	SIDM00193	Colorectal Carcinoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.2778
p.K245N	ACH-000991	Colon/Colorectal Cancer	CCLE	PWTPSPS	DEG_SCF_FBW7_1	0.2778
p.K245N	SNU-81	large_intestine	COSMIC	PWTPSPS	DEG_SCF_FBW7_1	0.2778
p.E233K	TCGA-D3-A5GO	SKCM	TCGA	PWTPSPS	DEG_SCF_FBW7_1	0.2222
p.E244D	TCGA-GC-A3RB	BLCA	TCGA	PWTPSPS	DEG_SCF_FBW7_1	0.3056
p.P240S	TCGA-XF-A8HD	BLCA	TCGA	PWTPSPS	DEG_SCF_FBW7_1	0.6752
p.S230N	TCGA-ZF-AA4N	BLCA	TCGA	PWTPSPS	DEG_SCF_FBW7_1	0.1389
p.S230N	DO219082	BLCA	ICGC	PWTPSPS	DEG_SCF_FBW7_1	0.1389
p.S230N	DO231954	LICA	ICGC	PWTPSPS	DEG_SCF_FBW7_1	0.1389
p.A244S	DO228974	LICA	ICGC	PWTPSPS	DEG_SCF_FBW7_1	0.3056
p.S235I	DO229029	LICA	ICGC	PWTPSPS	DEG_SCF_FBW7_1	0.2778
p.W251R	SIDM00845	Burkitt's Lymphoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.1111
p.W251R	SIDM01090	Colorectal Carcinoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.1111
p.W251R	SIDM01245	T-Lymphoblastic Leukemia	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.1111
p.W251R	SIDM00087	Plasma Cell Myeloma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.1111
p.W251R	SIDM00844	Burkitt's Lymphoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.1111
p.W251R	SIDM00907	Burkitt's Lymphoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.1111
p.W251R	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.1111
p.W251R	SIDM00621	Ewing's Sarcoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.1111
p.W251R	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.1111
p.W251R	SIDM00479	Esophageal Carcinoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.1111
p.W251R	SIDM00991	T-Lymphoblastic Leukemia	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.1111
p.E244K	SIDM00445	Esophageal Carcinoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.3056
p.E244K	OACp4C	oesophagus	COSMIC	PWTPSPS	DEG_SCF_FBW7_1	0.3056
p.E244K	NCI-H187	lung	COSMIC	PWTPSPS	DEG_SCF_FBW7_1	0.3056
p.T236M	SIDM00251	Gastric Carcinoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.3056
p.T236M	ACH-000949	Gastric Cancer	CCLE	PWTPSPS	DEG_SCF_FBW7_1	0.3056
p.T236M	TGBC11TKB	stomach	COSMIC	PWTPSPS	DEG_SCF_FBW7_1	0.3056
p.L229P	MFE-319	endometrium	COSMIC	PWTPSPS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q76M96	Coiled-coil domain-containing protein 80	DEG_SCF_FBW7_1	387:393	PWTPSPS	FBXW7	0.957	More...
Q2TAL5	Smoothelin-like protein 2	DEG_SCF_FBW7_1	237:243	PWTPSPS	FBXW7	0.9895	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PWTPSPS

Degron related mutations and impact score

Drug responses associated with SMTNL2 mutations

All proteins holding degron of PWTPSPS