DegronMD - Q76M96(CCDC80)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R374S	TCGA-25-2391	OV	TCGA	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.3056
p.R374S	DO31769	OV	ICGC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.3056
p.R386G	TCGA-55-8205	LUAD	TCGA	PWTPSPS	DEG_SCF_FBW7_1	387:393	Mutation rewiring degron network	0.3056
p.R386G	TCGA-55-8205	LUAD	TCGA	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1389
p.R386G	TCGA-55-8205	LUAD	TCGA	PPTTT	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.0556
p.R386G	DO48884	LUAD	ICGC	PWTPSPS	DEG_SCF_FBW7_1	387:393	Mutation rewiring degron network	0.3056
p.R386G	DO48884	LUAD	ICGC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1389
p.R386G	DO48884	LUAD	ICGC	PPTTT	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.0556
p.T384M	TCGA-AA-3994	COAD	TCGA	PWTPSPS	DEG_SCF_FBW7_1	387:393	Mutation rewiring degron network	0.25
p.T384M	TCGA-AA-3994	COAD	TCGA	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.T384M	DO8658	COAD	ICGC	PWTPSPS	DEG_SCF_FBW7_1	387:393	Mutation rewiring degron network	0.25
p.T384M	DO8658	COAD	ICGC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.T384M	DO234179	ESAD	ICGC	PWTPSPS	DEG_SCF_FBW7_1	387:393	Mutation rewiring degron network	0.25
p.T384M	DO234179	ESAD	ICGC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.T384M	SIDM01020	Plasma Cell Myeloma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	387:393	Mutation rewiring degron network	0.25
p.T384M	SIDM01020	Plasma Cell Myeloma	GDSC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.T384M	SIDM00578	Neuroblastoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	387:393	Mutation rewiring degron network	0.25
p.T384M	SIDM00578	Neuroblastoma	GDSC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.T384M	SIDM00216	Colorectal Carcinoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	387:393	Mutation rewiring degron network	0.25
p.T384M	SIDM00216	Colorectal Carcinoma	GDSC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.T384M	SIDM00584	Osteosarcoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	387:393	Mutation rewiring degron network	0.25
p.T384M	SIDM00584	Osteosarcoma	GDSC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.T384M	SIDM00555	Glioblastoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	387:393	Mutation rewiring degron network	0.25
p.T384M	SIDM00555	Glioblastoma	GDSC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.T384M	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	387:393	Mutation rewiring degron network	0.25
p.T384M	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.T384M	SIDM00235	Kidney Carcinoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	387:393	Mutation rewiring degron network	0.25
p.T384M	SIDM00235	Kidney Carcinoma	GDSC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.T384M	SIDM00567	Other Solid Cancers	GDSC	PWTPSPS	DEG_SCF_FBW7_1	387:393	Mutation rewiring degron network	0.25
p.T384M	SIDM00567	Other Solid Cancers	GDSC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.T384M	SIDM00279	Gastric Carcinoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	387:393	Mutation rewiring degron network	0.25
p.T384M	SIDM00279	Gastric Carcinoma	GDSC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.T384M	SIDM01695	Acute Myeloid Leukemia	GDSC	PWTPSPS	DEG_SCF_FBW7_1	387:393	Mutation rewiring degron network	0.25
p.T384M	SIDM01695	Acute Myeloid Leukemia	GDSC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.T384M	SIDM01685	B-Lymphoblastic Leukemia	GDSC	PWTPSPS	DEG_SCF_FBW7_1	387:393	Mutation rewiring degron network	0.25
p.T384M	SIDM01685	B-Lymphoblastic Leukemia	GDSC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.T384M	SIDM01574	Plasma Cell Myeloma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	387:393	Mutation rewiring degron network	0.25
p.T384M	SIDM01574	Plasma Cell Myeloma	GDSC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.T384M	NB1	autonomic ganglia	COSMIC	PWTPSPS	DEG_SCF_FBW7_1	387:393	Mutation rewiring degron network	0.25
p.T384M	NB1	autonomic ganglia	COSMIC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.T384M	SNU-175	large intestine	COSMIC	PWTPSPS	DEG_SCF_FBW7_1	387:393	Mutation rewiring degron network	0.25
p.T384M	SNU-175	large intestine	COSMIC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.T384M	KMS-12-BM	haematopoietic and lymphoid tissue	COSMIC	PWTPSPS	DEG_SCF_FBW7_1	387:393	Mutation rewiring degron network	0.25
p.T384M	KMS-12-BM	haematopoietic and lymphoid tissue	COSMIC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1944
p.A336T	TCGA-AJ-A3EL	UCEC	TCGA	PPSTPRAT	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.1111
p.A336T	DO41542	UCEC	ICGC	PPSTPRAT	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.1111
p.R407I	TCGA-AP-A051	UCEC	TCGA	PPTTT	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.1389
p.R407I	DO42673	UCEC	ICGC	PPTTT	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.1389
p.R395M	TCGA-AP-A051	UCEC	TCGA	PWTPSPS	DEG_SCF_FBW7_1	387:393	Mutation rewiring degron network	0.2778
p.R395M	TCGA-AP-A051	UCEC	TCGA	PPTTT	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.3056
p.R395M	DO42673	UCEC	ICGC	PWTPSPS	DEG_SCF_FBW7_1	387:393	Mutation rewiring degron network	0.2778
p.R395M	DO42673	UCEC	ICGC	PPTTT	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.3056
p.R395S	TCGA-AP-A054	UCEC	TCGA	PWTPSPS	DEG_SCF_FBW7_1	387:393	Mutation rewiring degron network	0.2778
p.R395S	TCGA-AP-A054	UCEC	TCGA	PPTTT	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.3056
p.R395S	DO42256	UCEC	ICGC	PWTPSPS	DEG_SCF_FBW7_1	387:393	Mutation rewiring degron network	0.2778
p.R395S	DO42256	UCEC	ICGC	PPTTT	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.3056
p.R406M	TCGA-BA-A6DA	HNSC	TCGA	PPTTT	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.1667
p.R406M	DO44448	HNSC	ICGC	PPTTT	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.1667
p.P345S	TCGA-D1-A17F	UCEC	TCGA	PPSTPRAT	DEG_SCF_FBW7_1	344:351	Mutation altering degron motif	0.5641
p.P345S	DO43362	UCEC	ICGC	PPSTPRAT	DEG_SCF_FBW7_1	344:351	Mutation altering degron motif	0.5641
p.A335V	TCGA-EY-A1GU	UCEC	TCGA	PPSTPRAT	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.0833
p.A335V	DO41518	UCEC	ICGC	PPSTPRAT	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.0833
p.A356P	DO48437	BLCA	ICGC	PPSTPRAT	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.1944
p.P342S	DO233089	GACA	ICGC	PPSTPRAT	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.2778
p.A368E	DO233649	GACA	ICGC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1389
p.T399A	DO228835	LICA	ICGC	PPTTT	DEG_SPOP_SBC_1	396:400	Mutation altering degron motif	0.7139
p.P354H	DO229018	LICA	ICGC	PPSTPRAT	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.25
p.T398K	DO229022	LICA	ICGC	PPTTT	DEG_SPOP_SBC_1	396:400	Mutation altering degron motif	0.7306
p.V371D	SIDM00303	Ovarian Carcinoma	GDSC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.2222
p.V371D	SIDM00491	Thyroid Gland Carcinoma	GDSC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.2222
p.V371D	ACH-000584	Ovarian Cancer	CCLE	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.2222
p.V371D	ACH-001443	Thyroid Cancer	CCLE	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.2222
p.V371D	JHOS-4	ovary	COSMIC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.2222
p.V371D	ASH-3	thyroid	COSMIC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.2222
p.R406G	SIDM00333	Endometrial Carcinoma	GDSC	PPTTT	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.1667
p.R406G	ACH-000988	Endometrial/Uterine Cancer	CCLE	PPTTT	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.1667
p.R406G	MFE-319	endometrium	COSMIC	PPTTT	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.1667
p.P397S	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PPTTT	DEG_SPOP_SBC_1	396:400	Mutation altering degron motif	0.5641
p.P397S	SIDM00807	Bladder Carcinoma	GDSC	PPTTT	DEG_SPOP_SBC_1	396:400	Mutation altering degron motif	0.5641
p.P397S	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PPTTT	DEG_SPOP_SBC_1	396:400	Mutation altering degron motif	0.5641
p.R367Q	SIDM00467	Acute Myeloid Leukemia	GDSC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1111
p.R367Q	SIDM01591	Breast Carcinoma	GDSC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1111
p.R367Q	QIMR-WIL	haematopoietic and lymphoid tissue	COSMIC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.1111
p.T351A	SIDM00217	Colorectal Carcinoma	GDSC	PPSTPRAT	DEG_SCF_FBW7_1	344:351	Mutation altering degron motif	0.825
p.T351A	ACH-000999	Colon/Colorectal Cancer	CCLE	PPSTPRAT	DEG_SCF_FBW7_1	344:351	Mutation altering degron motif	0.825
p.T351A	SNU-1040	large intestine	COSMIC	PPSTPRAT	DEG_SCF_FBW7_1	344:351	Mutation altering degron motif	0.825
p.A405S	SIDM01205	Acute Myeloid Leukemia	GDSC	PPTTT	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.1944
p.A405S	SIDM01195	Acute Myeloid Leukemia	GDSC	PPTTT	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.1944
p.A405S	ACH-002314	Leukemia	CCLE	PPTTT	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.1944
p.A405S	TUR	haematopoietic and lymphoid tissue	COSMIC	PPTTT	DEG_SPOP_SBC_1	396:400	Mutation rewiring degron network	0.1944
p.A340G	SIDM01490	Small Cell Lung Carcinoma	GDSC	PPSTPRAT	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.2222
p.T365M	SIDM01525	Acute Myeloid Leukemia	GDSC	PMTTT	DEG_SPOP_SBC_1	375:379	Mutation rewiring degron network	0.0556
p.A336S	ACH-000216	Esophageal Cancer	CCLE	PPSTPRAT	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC80

UniProt ID: Q76M96

Entrez ID: 151887

Protein name: Coiled-coil domain-containing protein 80 (Down-regulated by oncogenes protein 1) (Up-regulated in BRS-3 deficient mouse homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC80 in