DegronMD

Uniprot ID: Q76M96

Source protein: Coiled-coil domain-containing protein 80

Source gene: CCDC80

Class: DEG_SCF_FBW7_1

Location: 344:351

E3 ligase: FBXW7

DEGRON score: 0.9991

ASA_SCORE: 97.55

COIL: 0.9588

CONS_SCORE: 0.575

DSS_SCORE: 0.7239

HELIX: 0.0179

FCONS_SCORE: 1.266

RIG_SCORE: 0.619

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A336T	TCGA-AJ-A3EL	UCEC	TCGA	PPSTPRAT	DEG_SCF_FBW7_1	0.1111
p.A336T	DO41542	UCEC	ICGC	PPSTPRAT	DEG_SCF_FBW7_1	0.1111
p.P345S	TCGA-D1-A17F	UCEC	TCGA	PPSTPRAT	DEG_SCF_FBW7_1	0.5641
p.P345S	DO43362	UCEC	ICGC	PPSTPRAT	DEG_SCF_FBW7_1	0.5641
p.A335V	TCGA-EY-A1GU	UCEC	TCGA	PPSTPRAT	DEG_SCF_FBW7_1	0.0833
p.A335V	DO41518	UCEC	ICGC	PPSTPRAT	DEG_SCF_FBW7_1	0.0833
p.A356P	DO48437	BLCA	ICGC	PPSTPRAT	DEG_SCF_FBW7_1	0.1944
p.P342S	DO233089	GACA	ICGC	PPSTPRAT	DEG_SCF_FBW7_1	0.2778
p.P354H	DO229018	LICA	ICGC	PPSTPRAT	DEG_SCF_FBW7_1	0.25
p.T351A	SIDM00217	Colorectal Carcinoma	GDSC	PPSTPRAT	DEG_SCF_FBW7_1	0.825
p.T351A	ACH-000999	Colon/Colorectal Cancer	CCLE	PPSTPRAT	DEG_SCF_FBW7_1	0.825
p.T351A	SNU-1040	large_intestine	COSMIC	PPSTPRAT	DEG_SCF_FBW7_1	0.825
p.A340G	SIDM01490	Small Cell Lung Carcinoma	GDSC	PPSTPRAT	DEG_SCF_FBW7_1	0.2222
p.A336S	ACH-000216	Esophageal Cancer	CCLE	PPSTPRAT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q76M96	Coiled-coil domain-containing protein 80	DEG_SCF_FBW7_1	344:351	PPSTPRAT	FBXW7	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons