DegronMD

Uniprot ID: Q76M96

Source protein: Coiled-coil domain-containing protein 80

Source gene: CCDC80

Class: DEG_SPOP_SBC_1

Location: 375:379

E3 ligase: SPOP

DEGRON score: 0.9882

ASA_SCORE: 98.8

COIL: 0.9234

CONS_SCORE: 0.6867

DSS_SCORE: 0.6287

HELIX: 0.0212

FCONS_SCORE: 1.1687

RIG_SCORE: 0.717

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R374S	TCGA-25-2391	OV	TCGA	PMTTT	DEG_SPOP_SBC_1	0.3056
p.R374S	DO31769	OV	ICGC	PMTTT	DEG_SPOP_SBC_1	0.3056
p.R386G	TCGA-55-8205	LUAD	TCGA	PMTTT	DEG_SPOP_SBC_1	0.1389
p.R386G	DO48884	LUAD	ICGC	PMTTT	DEG_SPOP_SBC_1	0.1389
p.T384M	TCGA-AA-3994	COAD	TCGA	PMTTT	DEG_SPOP_SBC_1	0.1944
p.T384M	DO8658	COAD	ICGC	PMTTT	DEG_SPOP_SBC_1	0.1944
p.T384M	DO234179	ESAD	ICGC	PMTTT	DEG_SPOP_SBC_1	0.1944
p.T384M	SIDM01020	Plasma Cell Myeloma	GDSC	PMTTT	DEG_SPOP_SBC_1	0.1944
p.T384M	SIDM00578	Neuroblastoma	GDSC	PMTTT	DEG_SPOP_SBC_1	0.1944
p.T384M	SIDM00216	Colorectal Carcinoma	GDSC	PMTTT	DEG_SPOP_SBC_1	0.1944
p.T384M	SIDM00584	Osteosarcoma	GDSC	PMTTT	DEG_SPOP_SBC_1	0.1944
p.T384M	SIDM00555	Glioblastoma	GDSC	PMTTT	DEG_SPOP_SBC_1	0.1944
p.T384M	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	PMTTT	DEG_SPOP_SBC_1	0.1944
p.T384M	SIDM00235	Kidney Carcinoma	GDSC	PMTTT	DEG_SPOP_SBC_1	0.1944
p.T384M	SIDM00567	Other Solid Cancers	GDSC	PMTTT	DEG_SPOP_SBC_1	0.1944
p.T384M	SIDM00279	Gastric Carcinoma	GDSC	PMTTT	DEG_SPOP_SBC_1	0.1944
p.T384M	SIDM01695	Acute Myeloid Leukemia	GDSC	PMTTT	DEG_SPOP_SBC_1	0.1944
p.T384M	SIDM01685	B-Lymphoblastic Leukemia	GDSC	PMTTT	DEG_SPOP_SBC_1	0.1944
p.T384M	SIDM01574	Plasma Cell Myeloma	GDSC	PMTTT	DEG_SPOP_SBC_1	0.1944
p.T384M	NB1	autonomic_ganglia	COSMIC	PMTTT	DEG_SPOP_SBC_1	0.1944
p.T384M	SNU-175	large_intestine	COSMIC	PMTTT	DEG_SPOP_SBC_1	0.1944
p.T384M	KMS-12-BM	haematopoietic_and_lymphoid_tissue	COSMIC	PMTTT	DEG_SPOP_SBC_1	0.1944
p.A368E	DO233649	GACA	ICGC	PMTTT	DEG_SPOP_SBC_1	0.1389
p.V371D	SIDM00303	Ovarian Carcinoma	GDSC	PMTTT	DEG_SPOP_SBC_1	0.2222
p.V371D	SIDM00491	Thyroid Gland Carcinoma	GDSC	PMTTT	DEG_SPOP_SBC_1	0.2222
p.V371D	ACH-000584	Ovarian Cancer	CCLE	PMTTT	DEG_SPOP_SBC_1	0.2222
p.V371D	ACH-001443	Thyroid Cancer	CCLE	PMTTT	DEG_SPOP_SBC_1	0.2222
p.V371D	JHOS-4	ovary	COSMIC	PMTTT	DEG_SPOP_SBC_1	0.2222
p.V371D	ASH-3	thyroid	COSMIC	PMTTT	DEG_SPOP_SBC_1	0.2222
p.R367Q	SIDM00467	Acute Myeloid Leukemia	GDSC	PMTTT	DEG_SPOP_SBC_1	0.1111
p.R367Q	SIDM01591	Breast Carcinoma	GDSC	PMTTT	DEG_SPOP_SBC_1	0.1111
p.R367Q	QIMR-WIL	haematopoietic_and_lymphoid_tissue	COSMIC	PMTTT	DEG_SPOP_SBC_1	0.1111
p.T365M	SIDM01525	Acute Myeloid Leukemia	GDSC	PMTTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q76M96	Coiled-coil domain-containing protein 80	DEG_SPOP_SBC_1	375:379	PMTTT	SPOP	0.9882	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	175:179	PMTTT	SPOP	0.9833	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PMTTT

Degron related mutations and impact score

Drug responses associated with CCDC80 mutations

All proteins holding degron of PMTTT