DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
PMTTT
Uniprot ID:
Q9H195
Source protein:
Mucin-3B
Source gene:
MUC3B
Class:
DEG_SPOP_SBC_1
Location:
175:179
E3 ligase:
SPOP
DEGRON score:
0.9833
ASA_SCORE:
97.34
COIL:
0.9302
CONS_SCORE:
0.3886
DSS_SCORE:
0.5232
HELIX:
0.0202
FCONS_SCORE:
0.9568
RIG_SCORE:
0.7834
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MUC3B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PMTTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q76M96
Coiled-coil domain-containing protein 80
DEG_SPOP_SBC_1
375:379
PMTTT
SPOP
0.9882
More...
Q9H195
Mucin-3B
DEG_SPOP_SBC_1
175:179
PMTTT
SPOP
0.9833
More...