DegronMD

Uniprot ID: Q76M96

Source protein: Coiled-coil domain-containing protein 80

Source gene: CCDC80

Class: DEG_SCF_FBW7_1

Location: 387:393

E3 ligase: FBXW7

DEGRON score: 0.957

ASA_SCORE: 100.7857

COIL: 0.9683

CONS_SCORE: 0.4905

DSS_SCORE: 0.7355

HELIX: 0.0113

FCONS_SCORE: 0.8557

RIG_SCORE: 0.6058

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R386G	TCGA-55-8205	LUAD	TCGA	PWTPSPS	DEG_SCF_FBW7_1	0.3056
p.R386G	DO48884	LUAD	ICGC	PWTPSPS	DEG_SCF_FBW7_1	0.3056
p.T384M	TCGA-AA-3994	COAD	TCGA	PWTPSPS	DEG_SCF_FBW7_1	0.25
p.T384M	DO8658	COAD	ICGC	PWTPSPS	DEG_SCF_FBW7_1	0.25
p.T384M	DO234179	ESAD	ICGC	PWTPSPS	DEG_SCF_FBW7_1	0.25
p.T384M	SIDM01020	Plasma Cell Myeloma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.25
p.T384M	SIDM00578	Neuroblastoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.25
p.T384M	SIDM00216	Colorectal Carcinoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.25
p.T384M	SIDM00584	Osteosarcoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.25
p.T384M	SIDM00555	Glioblastoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.25
p.T384M	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.25
p.T384M	SIDM00235	Kidney Carcinoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.25
p.T384M	SIDM00567	Other Solid Cancers	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.25
p.T384M	SIDM00279	Gastric Carcinoma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.25
p.T384M	SIDM01695	Acute Myeloid Leukemia	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.25
p.T384M	SIDM01685	B-Lymphoblastic Leukemia	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.25
p.T384M	SIDM01574	Plasma Cell Myeloma	GDSC	PWTPSPS	DEG_SCF_FBW7_1	0.25
p.T384M	NB1	autonomic_ganglia	COSMIC	PWTPSPS	DEG_SCF_FBW7_1	0.25
p.T384M	SNU-175	large_intestine	COSMIC	PWTPSPS	DEG_SCF_FBW7_1	0.25
p.T384M	KMS-12-BM	haematopoietic_and_lymphoid_tissue	COSMIC	PWTPSPS	DEG_SCF_FBW7_1	0.25
p.R395M	TCGA-AP-A051	UCEC	TCGA	PWTPSPS	DEG_SCF_FBW7_1	0.2778
p.R395M	DO42673	UCEC	ICGC	PWTPSPS	DEG_SCF_FBW7_1	0.2778
p.R395S	TCGA-AP-A054	UCEC	TCGA	PWTPSPS	DEG_SCF_FBW7_1	0.2778
p.R395S	DO42256	UCEC	ICGC	PWTPSPS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q76M96	Coiled-coil domain-containing protein 80	DEG_SCF_FBW7_1	387:393	PWTPSPS	FBXW7	0.957	More...
Q2TAL5	Smoothelin-like protein 2	DEG_SCF_FBW7_1	237:243	PWTPSPS	FBXW7	0.9895	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PWTPSPS

Degron related mutations and impact score

Drug responses associated with CCDC80 mutations

All proteins holding degron of PWTPSPS