DegronMD

Uniprot ID: P10696

Source protein: Alkaline phosphatase, germ cell type

Source gene: ALPG

Class: DEG_SCF_FBW7_2

Location: 228:235

E3 ligase: FBXW7

DEGRON score: 0.9933

ASA_SCORE: 61.875

COIL: 0.8616

CONS_SCORE: 0.4955

DSS_SCORE: 0.5274

HELIX: 0.0361

FCONS_SCORE: 0.8415

RIG_SCORE: 0.6745

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G220V	SIDM00094	Kidney Carcinoma	GDSC	PMGTPDPE	DEG_SCF_FBW7_2	0.1111
p.G220V	SN12C	kidney	COSMIC	PMGTPDPE	DEG_SCF_FBW7_2	0.1111
p.E235K	SIDM00920	Breast Carcinoma	GDSC	PMGTPDPE	DEG_SCF_FBW7_2	0.7022
p.E235K	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PMGTPDPE	DEG_SCF_FBW7_2	0.7022
p.E235K	CAMA-1	breast	COSMIC	PMGTPDPE	DEG_SCF_FBW7_2	0.7022
p.E235K	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PMGTPDPE	DEG_SCF_FBW7_2	0.7022
p.P232S	SIDM00068	Colorectal Carcinoma	GDSC	PMGTPDPE	DEG_SCF_FBW7_2	0.6752
p.P232S	GEO	large_intestine	COSMIC	PMGTPDPE	DEG_SCF_FBW7_2	0.6752
p.G243S	Sarc9371	bone	COSMIC	PMGTPDPE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10696	Alkaline phosphatase, germ cell type	DEG_SCF_FBW7_2	228:235	PMGTPDPE	FBXW7	0.9933	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons