DegronMD

Uniprot ID: P16219

Source protein: Short-chain specific acyl-CoA dehydrogenase, mitochondrial

Source gene: ACADS

Class: DEG_SCF_FBW7_1

Location: 216:223

E3 ligase: FBXW7

DEGRON score: 0.8553

ASA_SCORE: 60.7625

COIL: 0.6701

CONS_SCORE: 0.5075

DSS_SCORE: 0.3179

HELIX: 0.0159

FCONS_SCORE: 0.8255

RIG_SCORE: 0.7471

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T219M	TCGA-5M-AAT6	COAD	TCGA	PMPTPGLT	DEG_SCF_FBW7_1	0.8534
p.K227T	TCGA-UY-A78K	BLCA	TCGA	PMPTPGLT	DEG_SCF_FBW7_1	0.3333
p.K223T	DO219031	BLCA	ICGC	PMPTPGLT	DEG_SCF_FBW7_1	0.7306
p.T215M	DO223703	COAD	ICGC	PMPTPGLT	DEG_SCF_FBW7_1	0.3056
p.T215M	DO233898	GACA	ICGC	PMPTPGLT	DEG_SCF_FBW7_1	0.3056
p.G221R	DO228139	PBCA	ICGC	PMPTPGLT	DEG_SCF_FBW7_1	0.6457
p.R230L	DO229410	PRAD	ICGC	PMPTPGLT	DEG_SCF_FBW7_1	0.25
p.M217I	SIDM01619	Endometrial Carcinoma	GDSC	PMPTPGLT	DEG_SCF_FBW7_1	0.6507
p.M217I	ACH-000984	Endometrial/Uterine Cancer	CCLE	PMPTPGLT	DEG_SCF_FBW7_1	0.6507

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P16219	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	DEG_SCF_FBW7_1	216:223	PMPTPGLT	FBXW7	0.8553	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons