DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_2

Location: 148:155

E3 ligase: FBXW7

DEGRON score: 0.7677

ASA_SCORE: 100.55

COIL: 0.9153

CONS_SCORE: 0.5236

DSS_SCORE: 0.6741

HELIX: 0.0228

FCONS_SCORE: 1

RIG_SCORE: 0.6442

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P152L	TCGA-BF-A3DM	SKCM	TCGA	PMSTPSEE	DEG_SCF_FBW7_2	0.7582
p.P152L	DO48667	SKCM	ICGC	PMSTPSEE	DEG_SCF_FBW7_2	0.7582
p.S158L	TCGA-C5-A1BK	CESC	TCGA	PMSTPSEE	DEG_SCF_FBW7_2	0.25
p.S158L	DO6266	CESC	ICGC	PMSTPSEE	DEG_SCF_FBW7_2	0.25
p.E143K	TCGA-EE-A2MR	SKCM	TCGA	PMSTPSEE	DEG_SCF_FBW7_2	0.1944
p.E143K	DO37819	SKCM	ICGC	PMSTPSEE	DEG_SCF_FBW7_2	0.1944
p.S159L	TCGA-GF-A6C9	SKCM	TCGA	PMSTPSEE	DEG_SCF_FBW7_2	0.2222
p.S159L	DO51254	SKCM	ICGC	PMSTPSEE	DEG_SCF_FBW7_2	0.2222
p.A162V	TCGA-Z2-A8RT	SKCM	TCGA	PMSTPSEE	DEG_SCF_FBW7_2	0.1389
p.A162V	DO51301	SKCM	ICGC	PMSTPSEE	DEG_SCF_FBW7_2	0.1389
p.S153N	DO227984	COCA	ICGC	PMSTPSEE	DEG_SCF_FBW7_2	0.5958
p.G144D	DO229016	COCA	ICGC	PMSTPSEE	DEG_SCF_FBW7_2	0.2222
p.G144D	DO230659	LAML	ICGC	PMSTPSEE	DEG_SCF_FBW7_2	0.2222
p.G144D	DO231140	LAML	ICGC	PMSTPSEE	DEG_SCF_FBW7_2	0.2222
p.G144D	DO228941	LICA	ICGC	PMSTPSEE	DEG_SCF_FBW7_2	0.2222
p.G144D	DO228947	LICA	ICGC	PMSTPSEE	DEG_SCF_FBW7_2	0.2222
p.G144D	DO229047	LICA	ICGC	PMSTPSEE	DEG_SCF_FBW7_2	0.2222
p.S156N	SIDM01099	Neuroblastoma	GDSC	PMSTPSEE	DEG_SCF_FBW7_2	0.3056
p.M161V	SIDM00014	Colorectal Carcinoma	GDSC	PMSTPSEE	DEG_SCF_FBW7_2	0.1667
p.M161V	LIM1215	large_intestine	COSMIC	PMSTPSEE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_2	148:155	PMSTPSEE	FBXW7	0.7677	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons