DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_2

Location: 1491:1498

E3 ligase: FBXW7

DEGRON score: 0.9718

ASA_SCORE: 100.2125

COIL: 0.925

CONS_SCORE: 0

DSS_SCORE: 0.562

HELIX: 0.028

FCONS_SCORE: 0

RIG_SCORE: 0.615

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1500P	TCGA-06-0125	GBM	TCGA	PMSTPSHE	DEG_SCF_FBW7_2	0.2778
p.S1500P	DO13510	GBM	ICGC	PMSTPSHE	DEG_SCF_FBW7_2	0.2778
p.S1507I	TCGA-37-A5EN	LUSC	TCGA	PMSTPSHE	DEG_SCF_FBW7_2	0.0833
p.S1507I	DO223720	LUSC	ICGC	PMSTPSHE	DEG_SCF_FBW7_2	0.0833
p.P1491H	TCGA-55-7994	LUAD	TCGA	PMSTPSHE	DEG_SCF_FBW7_2	0.7694
p.P1491H	DO45311	LUAD	ICGC	PMSTPSHE	DEG_SCF_FBW7_2	0.7694
p.T1494A	TCGA-BR-4201	STAD	TCGA	PMSTPSHE	DEG_SCF_FBW7_2	0.7139
p.T1494A	DO38707	STAD	ICGC	PMSTPSHE	DEG_SCF_FBW7_2	0.7139
p.P1491L	TCGA-BR-4257	STAD	TCGA	PMSTPSHE	DEG_SCF_FBW7_2	0.6471
p.P1491L	DO38683	STAD	ICGC	PMSTPSHE	DEG_SCF_FBW7_2	0.6471
p.S1493P	TCGA-CJ-5682	KIRC	TCGA	PMSTPSHE	DEG_SCF_FBW7_2	0.5641
p.S1493P	DO18056	KIRC	ICGC	PMSTPSHE	DEG_SCF_FBW7_2	0.5641
p.P1490L	TCGA-D3-A8GQ	SKCM	TCGA	PMSTPSHE	DEG_SCF_FBW7_2	0.3056
p.P1490L	TCGA-GN-A8LK	SKCM	TCGA	PMSTPSHE	DEG_SCF_FBW7_2	0.3056
p.P1490L	DO51259	SKCM	ICGC	PMSTPSHE	DEG_SCF_FBW7_2	0.3056
p.P1490L	DO51246	SKCM	ICGC	PMSTPSHE	DEG_SCF_FBW7_2	0.3056
p.T1506I	TCGA-DD-A39Z	LIHC	TCGA	PMSTPSHE	DEG_SCF_FBW7_2	0.1111
p.T1506I	DO44954	LIHC	ICGC	PMSTPSHE	DEG_SCF_FBW7_2	0.1111
p.P1490S	TCGA-EE-A29D	SKCM	TCGA	PMSTPSHE	DEG_SCF_FBW7_2	0.3056
p.P1490S	DO222595	MELA	ICGC	PMSTPSHE	DEG_SCF_FBW7_2	0.3056
p.P1490S	DO38123	SKCM	ICGC	PMSTPSHE	DEG_SCF_FBW7_2	0.3056
p.P1491S	TCGA-FD-A6TB	BLCA	TCGA	PMSTPSHE	DEG_SCF_FBW7_2	0.6752
p.P1491S	TCGA-FW-A3R5	SKCM	TCGA	PMSTPSHE	DEG_SCF_FBW7_2	0.6752
p.P1491S	DO51879	BLCA	ICGC	PMSTPSHE	DEG_SCF_FBW7_2	0.6752
p.P1491S	DO37406	SKCM	ICGC	PMSTPSHE	DEG_SCF_FBW7_2	0.6752
p.S1481L	TCGA-FS-A4FC	SKCM	TCGA	PMSTPSHE	DEG_SCF_FBW7_2	0.0556
p.S1481L	DO37762	SKCM	ICGC	PMSTPSHE	DEG_SCF_FBW7_2	0.0556
p.M1492I	TCGA-QT-A5XO	PCPG	TCGA	PMSTPSHE	DEG_SCF_FBW7_2	0.6507
p.A1504T	DO50349	ESAD	ICGC	PMSTPSHE	DEG_SCF_FBW7_2	0.1667
p.A1508D	DO229037	LICA	ICGC	PMSTPSHE	DEG_SCF_FBW7_2	0.0556
p.A1487D	DO232224	PBCA	ICGC	PMSTPSHE	DEG_SCF_FBW7_2	0.2222
p.L1499P	SIDM02070	Esophageal Carcinoma	GDSC	PMSTPSHE	DEG_SCF_FBW7_2	0.3056
p.H1497Y	SIDM00284	Melanoma	GDSC	PMSTPSHE	DEG_SCF_FBW7_2	0.6118
p.H1497Y	ACH-000805	Skin Cancer	CCLE	PMSTPSHE	DEG_SCF_FBW7_2	0.6118
p.H1497Y	COLO-679	skin	COSMIC	PMSTPSHE	DEG_SCF_FBW7_2	0.6118
p.S1481P	SIDM00498	Colorectal Carcinoma	GDSC	PMSTPSHE	DEG_SCF_FBW7_2	0.0556
p.S1481P	ACH-000970	Colon/Colorectal Cancer	CCLE	PMSTPSHE	DEG_SCF_FBW7_2	0.0556
p.S1481P	SNU-C5	large_intestine	COSMIC	PMSTPSHE	DEG_SCF_FBW7_2	0.0556
p.S1502P	SIDM00217	Colorectal Carcinoma	GDSC	PMSTPSHE	DEG_SCF_FBW7_2	0.2222
p.S1502P	ACH-000999	Colon/Colorectal Cancer	CCLE	PMSTPSHE	DEG_SCF_FBW7_2	0.2222
p.S1502P	SNU-1040	large_intestine	COSMIC	PMSTPSHE	DEG_SCF_FBW7_2	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PMSTPSHE

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PMSTPSHE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_2	1491:1498	PMSTPSHE	FBXW7	0.9718	More...