DegronMD

Uniprot ID: Q96PU8

Source protein: Protein quaking

Source gene: QKI

Class: DEG_SCF_FBW7_1

Location: 264:271

E3 ligase: FBXW7

DEGRON score: 0.8953

ASA_SCORE: 76.425

COIL: 0.9453

CONS_SCORE: 0.3515

DSS_SCORE: 0.497

HELIX: 0.0219

FCONS_SCORE: 0.8913

RIG_SCORE: 0.6412

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A261T	TCGA-63-A5MM	LUSC	TCGA	PNGTPHPT	DEG_SCF_FBW7_1	0.25
p.R256G	TCGA-AN-A0AK	BRCA	TCGA	PNGTPHPT	DEG_SCF_FBW7_1	0.1111
p.G266R	TCGA-B5-A0JR	UCEC	TCGA	PNGTPHPT	DEG_SCF_FBW7_1	0.6457
p.A281T	TCGA-EO-A22U	UCEC	TCGA	PNGTPHPT	DEG_SCF_FBW7_1	0.0556
p.G278W	TCGA-NJ-A4YQ	LUAD	TCGA	PNGTPHPT	DEG_SCF_FBW7_1	0.1389
p.G278W	DO218944	LUAD	ICGC	PNGTPHPT	DEG_SCF_FBW7_1	0.1389
p.P260A	DO233199	GACA	ICGC	PNGTPHPT	DEG_SCF_FBW7_1	0.2222
p.P269L	DO230950	LUSC	ICGC	PNGTPHPT	DEG_SCF_FBW7_1	0.7582
p.P269L	DO224638	LUSC	ICGC	PNGTPHPT	DEG_SCF_FBW7_1	0.7582
p.P260L	DO222494	MELA	ICGC	PNGTPHPT	DEG_SCF_FBW7_1	0.2222
p.P268S	DO222875	MELA	ICGC	PNGTPHPT	DEG_SCF_FBW7_1	0.6752
p.G258R	DO41791	UCEC	ICGC	PNGTPHPT	DEG_SCF_FBW7_1	0.1667
p.A273T	DO43755	UCEC	ICGC	PNGTPHPT	DEG_SCF_FBW7_1	0.2778
p.T271A	SIDM00050	Chondrosarcoma	GDSC	PNGTPHPT	DEG_SCF_FBW7_1	0.7139
p.T271A	ACH-002093	Bone Cancer	CCLE	PNGTPHPT	DEG_SCF_FBW7_1	0.7139
p.T271A	CHSA0108	bone	COSMIC	PNGTPHPT	DEG_SCF_FBW7_1	0.7139
p.I255F	SIDM00887	Other Solid Cancers	GDSC	PNGTPHPT	DEG_SCF_FBW7_1	0.0833
p.I255F	ACH-000211	Brain Cancer	CCLE	PNGTPHPT	DEG_SCF_FBW7_1	0.0833
p.I255F	Daoy	central_nervous_system	COSMIC	PNGTPHPT	DEG_SCF_FBW7_1	0.0833
p.T263A	CHSA0108	bone	COSMIC	PNGTPHPT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96PU8	Protein quaking	DEG_SCF_FBW7_1	264:271	PNGTPHPT	FBXW7	0.8953	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons