DegronMD - Q96PU8(QKI)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A261T	TCGA-63-A5MM	LUSC	TCGA	PNGTPHPT	DEG_SCF_FBW7_1	264:271	Mutation rewiring degron network	0.25
p.R53W	TCGA-AJ-A3EK	UCEC	TCGA	RKDMYND	LIG_APCC_ABBAyCdc20_2	53:59	Mutation altering degron motif	0.8634
p.R53W	DO41584	UCEC	ICGC	RKDMYND	LIG_APCC_ABBAyCdc20_2	53:59	Mutation altering degron motif	0.8634
p.R256G	TCGA-AN-A0AK	BRCA	TCGA	PNGTPHPT	DEG_SCF_FBW7_1	264:271	Mutation rewiring degron network	0.1111
p.G266R	TCGA-B5-A0JR	UCEC	TCGA	PNGTPHPT	DEG_SCF_FBW7_1	264:271	Mutation altering degron motif	0.6457
p.A281T	TCGA-EO-A22U	UCEC	TCGA	PNGTPHPT	DEG_SCF_FBW7_1	264:271	Mutation rewiring degron network	0.0556
p.G278W	TCGA-NJ-A4YQ	LUAD	TCGA	PNGTPHPT	DEG_SCF_FBW7_1	264:271	Mutation rewiring degron network	0.1389
p.G278W	DO218944	LUAD	ICGC	PNGTPHPT	DEG_SCF_FBW7_1	264:271	Mutation rewiring degron network	0.1389
p.P260A	DO233199	GACA	ICGC	PNGTPHPT	DEG_SCF_FBW7_1	264:271	Mutation rewiring degron network	0.2222
p.D59Y	DO229031	LICA	ICGC	RKDMYND	LIG_APCC_ABBAyCdc20_2	53:59	Mutation altering degron motif	0.7325
p.P269L	DO230950	LUSC	ICGC	PNGTPHPT	DEG_SCF_FBW7_1	264:271	Mutation altering degron motif	0.7582
p.P269L	DO224638	LUSC	ICGC	PNGTPHPT	DEG_SCF_FBW7_1	264:271	Mutation altering degron motif	0.7582
p.P260L	DO222494	MELA	ICGC	PNGTPHPT	DEG_SCF_FBW7_1	264:271	Mutation rewiring degron network	0.2222
p.P268S	DO222875	MELA	ICGC	PNGTPHPT	DEG_SCF_FBW7_1	264:271	Mutation altering degron motif	0.6752
p.G258R	DO41791	UCEC	ICGC	PNGTPHPT	DEG_SCF_FBW7_1	264:271	Mutation rewiring degron network	0.1667
p.A273T	DO43755	UCEC	ICGC	PNGTPHPT	DEG_SCF_FBW7_1	264:271	Mutation rewiring degron network	0.2778
p.G63V	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	RKDMYND	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.2222
p.G63V	ACH-000945	Lung Cancer	CCLE	RKDMYND	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.2222
p.G63V	NCI-H650	lung	COSMIC	RKDMYND	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.2222
p.T271A	SIDM00050	Chondrosarcoma	GDSC	PNGTPHPT	DEG_SCF_FBW7_1	264:271	Mutation altering degron motif	0.7139
p.T271A	ACH-002093	Bone Cancer	CCLE	PNGTPHPT	DEG_SCF_FBW7_1	264:271	Mutation altering degron motif	0.7139
p.T271A	CHSA0108	bone	COSMIC	PNGTPHPT	DEG_SCF_FBW7_1	264:271	Mutation altering degron motif	0.7139
p.I255F	SIDM00887	Other Solid Cancers	GDSC	PNGTPHPT	DEG_SCF_FBW7_1	264:271	Mutation rewiring degron network	0.0833
p.I255F	ACH-000211	Brain Cancer	CCLE	PNGTPHPT	DEG_SCF_FBW7_1	264:271	Mutation rewiring degron network	0.0833
p.I255F	Daoy	central nervous system	COSMIC	PNGTPHPT	DEG_SCF_FBW7_1	264:271	Mutation rewiring degron network	0.0833
p.R43Q	SIDM00363	Acute Myeloid Leukemia	GDSC	RKDMYND	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.0556
p.R43Q	ACH-000770	Leukemia	CCLE	RKDMYND	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.0556
p.R43Q	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	RKDMYND	LIG_APCC_ABBAyCdc20_2	53:59	Mutation rewiring degron network	0.0556
p.T263A	CHSA0108	bone	COSMIC	PNGTPHPT	DEG_SCF_FBW7_1	264:271	Mutation rewiring degron network	0.3056

Kaplan plot for QKI in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

QKI

UniProt ID: Q96PU8

Entrez ID: 9444

Protein name: Protein quaking (Hqk) (HqkI)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for QKI in