DegronMD

Uniprot ID: Q96PU8

Source protein: Protein quaking

Source gene: QKI

Class: LIG_APCC_ABBAyCdc20_2

Location: 53:59

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7262

ASA_SCORE: 89.8429

COIL: 0.3266

CONS_SCORE: 0.4951

DSS_SCORE: 0.3898

HELIX: 0.6639

FCONS_SCORE: 0.8498

RIG_SCORE: 0.7865

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R53W	TCGA-AJ-A3EK	UCEC	TCGA	RKDMYND	LIG_APCC_ABBAyCdc20_2	0.8634
p.R53W	DO41584	UCEC	ICGC	RKDMYND	LIG_APCC_ABBAyCdc20_2	0.8634
p.D59Y	DO229031	LICA	ICGC	RKDMYND	LIG_APCC_ABBAyCdc20_2	0.7325
p.G63V	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	RKDMYND	LIG_APCC_ABBAyCdc20_2	0.2222
p.G63V	ACH-000945	Lung Cancer	CCLE	RKDMYND	LIG_APCC_ABBAyCdc20_2	0.2222
p.G63V	NCI-H650	lung	COSMIC	RKDMYND	LIG_APCC_ABBAyCdc20_2	0.2222
p.R43Q	SIDM00363	Acute Myeloid Leukemia	GDSC	RKDMYND	LIG_APCC_ABBAyCdc20_2	0.0556
p.R43Q	ACH-000770	Leukemia	CCLE	RKDMYND	LIG_APCC_ABBAyCdc20_2	0.0556
p.R43Q	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	RKDMYND	LIG_APCC_ABBAyCdc20_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96PU8	Protein quaking	LIG_APCC_ABBAyCdc20_2	53:59	RKDMYND	APC,CDC20,FZR1	0.7262	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons