DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PNLTPPPT
Uniprot ID:
A1L4H1
Source protein:
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D
Source gene:
SSC5D
Class:
DEG_SCF_FBW7_1
Location:
1418:1425
E3 ligase:
FBXW7
DEGRON score:
0.8068
ASA_SCORE:
92.9
COIL:
0.967
CONS_SCORE:
0.363
DSS_SCORE:
0.8434
HELIX:
0.0138
FCONS_SCORE:
0.9419
RIG_SCORE:
0.4822
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.K1411E
TCGA-EY-A1GD
UCEC
TCGA
PNLTPPPT
DEG_SCF_FBW7_1
0.25
p.K1411E
DO42129
UCEC
ICGC
PNLTPPPT
DEG_SCF_FBW7_1
0.25
Drug responses associated with SSC5D mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PNLTPPPT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A1L4H1
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D
DEG_SCF_FBW7_1
1418:1425
PNLTPPPT
FBXW7
0.8068
More...