DegronMD

Uniprot ID: Q96RT7

Source protein: Gamma-tubulin complex component 6

Source gene: TUBGCP6

Class: DEG_SCF_FBW7_1

Location: 1358:1364

E3 ligase: FBXW7

DEGRON score: 0.9976

ASA_SCORE: 75.5571

COIL: 0.931

CONS_SCORE: 0.2723

DSS_SCORE: 0.7116

HELIX: 0.0336

FCONS_SCORE: 1.1335

RIG_SCORE: 0.6651

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1361Q	TCGA-46-3765	LUSC	TCGA	PNTPGDS	DEG_SCF_FBW7_1	0.7035
p.P1361Q	DO26959	LUSC	ICGC	PNTPGDS	DEG_SCF_FBW7_1	0.7035
p.P1352A	TCGA-AR-A0TX	BRCA	TCGA	PNTPGDS	DEG_SCF_FBW7_1	0.1667
p.P1352A	DO1663	BRCA	ICGC	PNTPGDS	DEG_SCF_FBW7_1	0.1667
p.S1364C	DO230334	COCA	ICGC	PNTPGDS	DEG_SCF_FBW7_1	0.7541
p.S1364C	DO229013	COCA	ICGC	PNTPGDS	DEG_SCF_FBW7_1	0.7541
p.S1364C	DO234285	ESAD	ICGC	PNTPGDS	DEG_SCF_FBW7_1	0.7541
p.S1364C	DO229047	LICA	ICGC	PNTPGDS	DEG_SCF_FBW7_1	0.7541
p.S1364C	DO230556	LUSC	ICGC	PNTPGDS	DEG_SCF_FBW7_1	0.7541
p.S1364C	DO231083	LUSC	ICGC	PNTPGDS	DEG_SCF_FBW7_1	0.7541
p.S1364C	DO231022	LUSC	ICGC	PNTPGDS	DEG_SCF_FBW7_1	0.7541
p.V1374M	DO234303	ESAD	ICGC	PNTPGDS	DEG_SCF_FBW7_1	0.0556
p.S1348P	DO233179	GACA	ICGC	PNTPGDS	DEG_SCF_FBW7_1	0.0556
p.T1360N	DO229028	LICA	ICGC	PNTPGDS	DEG_SCF_FBW7_1	0.7055
p.P1358H	DO229026	LICA	ICGC	PNTPGDS	DEG_SCF_FBW7_1	0.7694
p.W1356L	DO232826	NACA	ICGC	PNTPGDS	DEG_SCF_FBW7_1	0.2778
p.R1373M	DO47849	STAD	ICGC	PNTPGDS	DEG_SCF_FBW7_1	0.0833
p.G1362R	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	PNTPGDS	DEG_SCF_FBW7_1	0.6457
p.G1362R	ACH-002263	Esophageal Cancer	CCLE	PNTPGDS	DEG_SCF_FBW7_1	0.6457
p.G1362R	KYSE-220	oesophagus	COSMIC	PNTPGDS	DEG_SCF_FBW7_1	0.6457

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RT7	Gamma-tubulin complex component 6	DEG_SCF_FBW7_1	1358:1364	PNTPGDS	FBXW7	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons