DegronMD - Q96RT7(TUBGCP6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1361Q	TCGA-46-3765	LUSC	TCGA	PNTPGDS	DEG_SCF_FBW7_1	1358:1364	Mutation altering degron motif	0.7035
p.P1361Q	DO26959	LUSC	ICGC	PNTPGDS	DEG_SCF_FBW7_1	1358:1364	Mutation altering degron motif	0.7035
p.P1352A	TCGA-AR-A0TX	BRCA	TCGA	PNTPGDS	DEG_SCF_FBW7_1	1358:1364	Mutation rewiring degron network	0.1667
p.P1352A	DO1663	BRCA	ICGC	PNTPGDS	DEG_SCF_FBW7_1	1358:1364	Mutation rewiring degron network	0.1667
p.T223I	TCGA-IB-7651	PAAD	TCGA	VRLGLPPVP	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.1944
p.T223I	DO46657	PAAD	ICGC	VRLGLPPVP	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.1944
p.A239V	TCGA-LG-A6GG	LIHC	TCGA	VRLGLPPVP	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.25
p.A239V	DO49699	LIHC	ICGC	VRLGLPPVP	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.25
p.S1364C	DO230334	COCA	ICGC	PNTPGDS	DEG_SCF_FBW7_1	1358:1364	Mutation altering degron motif	0.7541
p.S1364C	DO229013	COCA	ICGC	PNTPGDS	DEG_SCF_FBW7_1	1358:1364	Mutation altering degron motif	0.7541
p.S1364C	DO234285	ESAD	ICGC	PNTPGDS	DEG_SCF_FBW7_1	1358:1364	Mutation altering degron motif	0.7541
p.S1364C	DO229047	LICA	ICGC	PNTPGDS	DEG_SCF_FBW7_1	1358:1364	Mutation altering degron motif	0.7541
p.S1364C	DO230556	LUSC	ICGC	PNTPGDS	DEG_SCF_FBW7_1	1358:1364	Mutation altering degron motif	0.7541
p.S1364C	DO231083	LUSC	ICGC	PNTPGDS	DEG_SCF_FBW7_1	1358:1364	Mutation altering degron motif	0.7541
p.S1364C	DO231022	LUSC	ICGC	PNTPGDS	DEG_SCF_FBW7_1	1358:1364	Mutation altering degron motif	0.7541
p.V1374M	DO234303	ESAD	ICGC	PNTPGDS	DEG_SCF_FBW7_1	1358:1364	Mutation rewiring degron network	0.0556
p.S1348P	DO233179	GACA	ICGC	PNTPGDS	DEG_SCF_FBW7_1	1358:1364	Mutation rewiring degron network	0.0556
p.R222H	DO233935	GACA	ICGC	VRLGLPPVP	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.1667
p.T1360N	DO229028	LICA	ICGC	PNTPGDS	DEG_SCF_FBW7_1	1358:1364	Mutation altering degron motif	0.7055
p.P1358H	DO229026	LICA	ICGC	PNTPGDS	DEG_SCF_FBW7_1	1358:1364	Mutation altering degron motif	0.7694
p.D240E	DO229045	LICA	ICGC	VRLGLPPVP	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.2222
p.W1356L	DO232826	NACA	ICGC	PNTPGDS	DEG_SCF_FBW7_1	1358:1364	Mutation rewiring degron network	0.2778
p.R1373M	DO47849	STAD	ICGC	PNTPGDS	DEG_SCF_FBW7_1	1358:1364	Mutation rewiring degron network	0.0833
p.H220R	SIDM00884	Breast Carcinoma	GDSC	VRLGLPPVP	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.1111
p.H220R	ACH-000699	Breast Cancer	CCLE	VRLGLPPVP	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.1111
p.H220R	HCC1395	breast	COSMIC	VRLGLPPVP	DEG_APCC_DBOX_1	228:236	Mutation rewiring degron network	0.1111
p.G1362R	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	PNTPGDS	DEG_SCF_FBW7_1	1358:1364	Mutation altering degron motif	0.6457
p.G1362R	ACH-002263	Esophageal Cancer	CCLE	PNTPGDS	DEG_SCF_FBW7_1	1358:1364	Mutation altering degron motif	0.6457
p.G1362R	KYSE-220	oesophagus	COSMIC	PNTPGDS	DEG_SCF_FBW7_1	1358:1364	Mutation altering degron motif	0.6457
p.V235A	ACH-001390	Breast Cancer	CCLE	VRLGLPPVP	DEG_APCC_DBOX_1	228:236	Mutation altering degron motif	0.6936

Kaplan plot for TUBGCP6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TUBGCP6

UniProt ID: Q96RT7

Entrez ID: 85378

Protein name: Gamma-tubulin complex component 6 (GCP-6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TUBGCP6 in