DegronMD

Uniprot ID: Q96RT7

Source protein: Gamma-tubulin complex component 6

Source gene: TUBGCP6

Class: DEG_APCC_DBOX_1

Location: 228:236

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.962

ASA_SCORE: 66.1111

COIL: 0.8489

CONS_SCORE: 0.4948

DSS_SCORE: 0.3546

HELIX: 0.0606

FCONS_SCORE: 1.1573

RIG_SCORE: 0.7536

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T223I	TCGA-IB-7651	PAAD	TCGA	VRLGLPPVP	DEG_APCC_DBOX_1	0.1944
p.T223I	DO46657	PAAD	ICGC	VRLGLPPVP	DEG_APCC_DBOX_1	0.1944
p.A239V	TCGA-LG-A6GG	LIHC	TCGA	VRLGLPPVP	DEG_APCC_DBOX_1	0.25
p.A239V	DO49699	LIHC	ICGC	VRLGLPPVP	DEG_APCC_DBOX_1	0.25
p.R222H	DO233935	GACA	ICGC	VRLGLPPVP	DEG_APCC_DBOX_1	0.1667
p.D240E	DO229045	LICA	ICGC	VRLGLPPVP	DEG_APCC_DBOX_1	0.2222
p.H220R	SIDM00884	Breast Carcinoma	GDSC	VRLGLPPVP	DEG_APCC_DBOX_1	0.1111
p.H220R	ACH-000699	Breast Cancer	CCLE	VRLGLPPVP	DEG_APCC_DBOX_1	0.1111
p.H220R	HCC1395	breast	COSMIC	VRLGLPPVP	DEG_APCC_DBOX_1	0.1111
p.V235A	ACH-001390	Breast Cancer	CCLE	VRLGLPPVP	DEG_APCC_DBOX_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RT7	Gamma-tubulin complex component 6	DEG_APCC_DBOX_1	228:236	VRLGLPPVP	APC,CDC20,FZR1	0.962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons