DegronMD

Uniprot ID: Q6NUP7

Source protein: Serine/threonine-protein phosphatase 4 regulatory subunit 4

Source gene: PPP4R4

Class: DEG_SCF_FBW7_1

Location: 834:840

E3 ligase: FBXW7

DEGRON score: 0.9969

ASA_SCORE: 102.8571

COIL: 0.972

CONS_SCORE: 0.3537

DSS_SCORE: 0.6693

HELIX: 0.0106

FCONS_SCORE: 1.0391

RIG_SCORE: 0.5679

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L838S	TCGA-A2-A0SW	BRCA	TCGA	PNTPLPS	DEG_SCF_FBW7_1	0.6556
p.L838S	DO4491	BRCA	ICGC	PNTPLPS	DEG_SCF_FBW7_1	0.6556
p.S827R	TCGA-AJ-A3BH	UCEC	TCGA	PNTPLPS	DEG_SCF_FBW7_1	0.1389
p.S827R	DO41638	UCEC	ICGC	PNTPLPS	DEG_SCF_FBW7_1	0.1389
p.S831F	TCGA-BF-A1Q0	SKCM	TCGA	PNTPLPS	DEG_SCF_FBW7_1	0.25
p.S831F	DO47374	SKCM	ICGC	PNTPLPS	DEG_SCF_FBW7_1	0.25
p.T836A	TCGA-BH-A1FU	BRCA	TCGA	PNTPLPS	DEG_SCF_FBW7_1	0.7139
p.T836A	DO6128	BRCA	ICGC	PNTPLPS	DEG_SCF_FBW7_1	0.7139
p.P829L	TCGA-C5-A1ML	CESC	TCGA	PNTPLPS	DEG_SCF_FBW7_1	0.1944
p.P829L	DO51592	CESC	ICGC	PNTPLPS	DEG_SCF_FBW7_1	0.1944
p.R843H	TCGA-DA-A95X	SKCM	TCGA	PNTPLPS	DEG_SCF_FBW7_1	0.25
p.R843H	TCGA-VQ-A8PP	STAD	TCGA	PNTPLPS	DEG_SCF_FBW7_1	0.25
p.R843H	DO229130	NKTL	ICGC	PNTPLPS	DEG_SCF_FBW7_1	0.25
p.R843H	DO219480	SKCM	ICGC	PNTPLPS	DEG_SCF_FBW7_1	0.25
p.R843H	DO51774	STAD	ICGC	PNTPLPS	DEG_SCF_FBW7_1	0.25
p.P834H	TCGA-EO-A3B0	UCEC	TCGA	PNTPLPS	DEG_SCF_FBW7_1	0.7694
p.P834H	DO219773	UCEC	ICGC	PNTPLPS	DEG_SCF_FBW7_1	0.7694
p.S842F	TCGA-EU-5904	KIRC	TCGA	PNTPLPS	DEG_SCF_FBW7_1	0.2778
p.S842F	TCGA-FW-A5DX	SKCM	TCGA	PNTPLPS	DEG_SCF_FBW7_1	0.2778
p.S842F	DO223033	ESCA	ICGC	PNTPLPS	DEG_SCF_FBW7_1	0.2778
p.S842F	DO17482	KIRC	ICGC	PNTPLPS	DEG_SCF_FBW7_1	0.2778
p.S842F	DO47253	SKCM	ICGC	PNTPLPS	DEG_SCF_FBW7_1	0.2778
p.P839L	SIDM00529	Breast Carcinoma	GDSC	PNTPLPS	DEG_SCF_FBW7_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NUP7	Serine/threonine-protein phosphatase 4 regulatory subunit 4	DEG_SCF_FBW7_1	834:840	PNTPLPS	FBXW7	0.9969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons