DegronMD - Q6NUP7(PPP4R4)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L838S	TCGA-A2-A0SW	BRCA	TCGA	PNTPLPS	DEG_SCF_FBW7_1	834:840	Mutation altering degron motif	0.6556
p.L838S	DO4491	BRCA	ICGC	PNTPLPS	DEG_SCF_FBW7_1	834:840	Mutation altering degron motif	0.6556
p.S756F	TCGA-AA-A02R	COAD	TCGA	VTPSTS	DEG_SCF_FBW7_1	757:762	Mutation blocking phosphorylation signal	0.75
p.S827R	TCGA-AJ-A3BH	UCEC	TCGA	PNTPLPS	DEG_SCF_FBW7_1	834:840	Mutation rewiring degron network	0.1389
p.S827R	DO41638	UCEC	ICGC	PNTPLPS	DEG_SCF_FBW7_1	834:840	Mutation rewiring degron network	0.1389
p.R772Q	TCGA-B5-A11N	UCEC	TCGA	VTPSTS	DEG_SCF_FBW7_1	757:762	Mutation rewiring degron network	0.0556
p.R772Q	TCGA-ZG-A9LZ	PRAD	TCGA	VTPSTS	DEG_SCF_FBW7_1	757:762	Mutation rewiring degron network	0.0556
p.R772Q	DO219440	PRAD	ICGC	VTPSTS	DEG_SCF_FBW7_1	757:762	Mutation rewiring degron network	0.0556
p.R772Q	DO41458	UCEC	ICGC	VTPSTS	DEG_SCF_FBW7_1	757:762	Mutation rewiring degron network	0.0556
p.S831F	TCGA-BF-A1Q0	SKCM	TCGA	PNTPLPS	DEG_SCF_FBW7_1	834:840	Mutation rewiring degron network	0.25
p.S831F	DO47374	SKCM	ICGC	PNTPLPS	DEG_SCF_FBW7_1	834:840	Mutation rewiring degron network	0.25
p.T836A	TCGA-BH-A1FU	BRCA	TCGA	PNTPLPS	DEG_SCF_FBW7_1	834:840	Mutation altering degron motif	0.7139
p.T836A	DO6128	BRCA	ICGC	PNTPLPS	DEG_SCF_FBW7_1	834:840	Mutation altering degron motif	0.7139
p.P829L	TCGA-C5-A1ML	CESC	TCGA	PNTPLPS	DEG_SCF_FBW7_1	834:840	Mutation rewiring degron network	0.1944
p.P829L	DO51592	CESC	ICGC	PNTPLPS	DEG_SCF_FBW7_1	834:840	Mutation rewiring degron network	0.1944
p.R843H	TCGA-DA-A95X	SKCM	TCGA	PNTPLPS	DEG_SCF_FBW7_1	834:840	Mutation rewiring degron network	0.25
p.R843H	TCGA-VQ-A8PP	STAD	TCGA	PNTPLPS	DEG_SCF_FBW7_1	834:840	Mutation rewiring degron network	0.25
p.R843H	DO229130	NKTL	ICGC	PNTPLPS	DEG_SCF_FBW7_1	834:840	Mutation rewiring degron network	0.25
p.R843H	DO219480	SKCM	ICGC	PNTPLPS	DEG_SCF_FBW7_1	834:840	Mutation rewiring degron network	0.25
p.R843H	DO51774	STAD	ICGC	PNTPLPS	DEG_SCF_FBW7_1	834:840	Mutation rewiring degron network	0.25
p.K766N	TCGA-E6-A1LX	UCEC	TCGA	VTPSTS	DEG_SCF_FBW7_1	757:762	Mutation substituting flanking lysine	0.3333
p.K766N	TCGA-EO-A3B0	UCEC	TCGA	VTPSTS	DEG_SCF_FBW7_1	757:762	Mutation substituting flanking lysine	0.3333
p.K766N	DO219773	UCEC	ICGC	VTPSTS	DEG_SCF_FBW7_1	757:762	Mutation substituting flanking lysine	0.3333
p.K766N	DO41020	UCEC	ICGC	VTPSTS	DEG_SCF_FBW7_1	757:762	Mutation substituting flanking lysine	0.3333
p.G753V	TCGA-EE-A181	SKCM	TCGA	VTPSTS	DEG_SCF_FBW7_1	757:762	Mutation rewiring degron network	0.2222
p.G753V	DO37444	SKCM	ICGC	VTPSTS	DEG_SCF_FBW7_1	757:762	Mutation rewiring degron network	0.2222
p.S760L	TCGA-EE-A181	SKCM	TCGA	VTPSTS	DEG_SCF_FBW7_1	757:762	Mutation altering degron motif	0.7667
p.S760L	DO37444	SKCM	ICGC	VTPSTS	DEG_SCF_FBW7_1	757:762	Mutation altering degron motif	0.7667
p.P834H	TCGA-EO-A3B0	UCEC	TCGA	PNTPLPS	DEG_SCF_FBW7_1	834:840	Mutation altering degron motif	0.7694
p.P834H	DO219773	UCEC	ICGC	PNTPLPS	DEG_SCF_FBW7_1	834:840	Mutation altering degron motif	0.7694
p.S842F	TCGA-EU-5904	KIRC	TCGA	PNTPLPS	DEG_SCF_FBW7_1	834:840	Mutation rewiring degron network	0.2778
p.S842F	TCGA-FW-A5DX	SKCM	TCGA	PNTPLPS	DEG_SCF_FBW7_1	834:840	Mutation rewiring degron network	0.2778
p.S842F	DO223033	ESCA	ICGC	PNTPLPS	DEG_SCF_FBW7_1	834:840	Mutation rewiring degron network	0.2778
p.S842F	DO17482	KIRC	ICGC	PNTPLPS	DEG_SCF_FBW7_1	834:840	Mutation rewiring degron network	0.2778
p.S842F	DO47253	SKCM	ICGC	PNTPLPS	DEG_SCF_FBW7_1	834:840	Mutation rewiring degron network	0.2778
p.R772G	TCGA-GD-A2C5	BLCA	TCGA	VTPSTS	DEG_SCF_FBW7_1	757:762	Mutation rewiring degron network	0.0556
p.R772G	DO496	BLCA	ICGC	VTPSTS	DEG_SCF_FBW7_1	757:762	Mutation rewiring degron network	0.0556
p.I771S	TCGA-ZF-A9RC	BLCA	TCGA	VTPSTS	DEG_SCF_FBW7_1	757:762	Mutation rewiring degron network	0.0833
p.I771S	DO219068	BLCA	ICGC	VTPSTS	DEG_SCF_FBW7_1	757:762	Mutation rewiring degron network	0.0833
p.S760W	DO222867	BTCA	ICGC	VTPSTS	DEG_SCF_FBW7_1	757:762	Mutation altering degron motif	0.7874
p.P839L	SIDM00529	Breast Carcinoma	GDSC	PNTPLPS	DEG_SCF_FBW7_1	834:840	Mutation altering degron motif	0.6471

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPP4R4

UniProt ID: Q6NUP7

Entrez ID: 57718

Protein name: Serine/threonine-protein phosphatase 4 regulatory subunit 4

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PPP4R4 in