DegronMD

Uniprot ID: Q6NUP7

Source protein: Serine/threonine-protein phosphatase 4 regulatory subunit 4

Source gene: PPP4R4

Class: DEG_SCF_FBW7_1

Location: 757:762

E3 ligase: FBXW7

DEGRON score: 0.9929

ASA_SCORE: 85.9333

COIL: 0.918

CONS_SCORE: 0.3353

DSS_SCORE: 0.5925

HELIX: 0.0548

FCONS_SCORE: 1.1133

RIG_SCORE: 0.6441

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S756F	TCGA-AA-A02R	COAD	TCGA	VTPSTS	DEG_SCF_FBW7_1	0.75
p.R772Q	TCGA-B5-A11N	UCEC	TCGA	VTPSTS	DEG_SCF_FBW7_1	0.0556
p.R772Q	TCGA-ZG-A9LZ	PRAD	TCGA	VTPSTS	DEG_SCF_FBW7_1	0.0556
p.R772Q	DO219440	PRAD	ICGC	VTPSTS	DEG_SCF_FBW7_1	0.0556
p.R772Q	DO41458	UCEC	ICGC	VTPSTS	DEG_SCF_FBW7_1	0.0556
p.K766N	TCGA-E6-A1LX	UCEC	TCGA	VTPSTS	DEG_SCF_FBW7_1	0.3333
p.K766N	TCGA-EO-A3B0	UCEC	TCGA	VTPSTS	DEG_SCF_FBW7_1	0.3333
p.K766N	DO219773	UCEC	ICGC	VTPSTS	DEG_SCF_FBW7_1	0.3333
p.K766N	DO41020	UCEC	ICGC	VTPSTS	DEG_SCF_FBW7_1	0.3333
p.G753V	TCGA-EE-A181	SKCM	TCGA	VTPSTS	DEG_SCF_FBW7_1	0.2222
p.G753V	DO37444	SKCM	ICGC	VTPSTS	DEG_SCF_FBW7_1	0.2222
p.S760L	TCGA-EE-A181	SKCM	TCGA	VTPSTS	DEG_SCF_FBW7_1	0.7667
p.S760L	DO37444	SKCM	ICGC	VTPSTS	DEG_SCF_FBW7_1	0.7667
p.R772G	TCGA-GD-A2C5	BLCA	TCGA	VTPSTS	DEG_SCF_FBW7_1	0.0556
p.R772G	DO496	BLCA	ICGC	VTPSTS	DEG_SCF_FBW7_1	0.0556
p.I771S	TCGA-ZF-A9RC	BLCA	TCGA	VTPSTS	DEG_SCF_FBW7_1	0.0833
p.I771S	DO219068	BLCA	ICGC	VTPSTS	DEG_SCF_FBW7_1	0.0833
p.S760W	DO222867	BTCA	ICGC	VTPSTS	DEG_SCF_FBW7_1	0.7874

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6NUP7	Serine/threonine-protein phosphatase 4 regulatory subunit 4	DEG_SCF_FBW7_1	757:762	VTPSTS	FBXW7	0.9929	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons