DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 3721:3727

E3 ligase: FBXW7

DEGRON score: 0.7529

ASA_SCORE: 89.9857

COIL: 0.8889

CONS_SCORE: 0

DSS_SCORE: 0.4094

HELIX: 0.0236

FCONS_SCORE: 0

RIG_SCORE: 0.7514

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H3714Q	TCGA-68-8250	LUSC	TCGA	PNTPLST	DEG_SCF_FBW7_1	0.1389
p.H3714Q	DO26993	LUSC	ICGC	PNTPLST	DEG_SCF_FBW7_1	0.1389
p.L3733Q	TCGA-73-4670	LUAD	TCGA	PNTPLST	DEG_SCF_FBW7_1	0.1667
p.L3733Q	DO25350	LUAD	ICGC	PNTPLST	DEG_SCF_FBW7_1	0.1667
p.S3711Y	TCGA-AA-3977	COAD	TCGA	PNTPLST	DEG_SCF_FBW7_1	0.0556
p.S3711Y	DO8730	COAD	ICGC	PNTPLST	DEG_SCF_FBW7_1	0.0556
p.S3711Y	DO222762	COCA	ICGC	PNTPLST	DEG_SCF_FBW7_1	0.0556
p.S3732T	TCGA-BP-4993	KIRC	TCGA	PNTPLST	DEG_SCF_FBW7_1	0.1944
p.S3732T	DO20171	KIRC	ICGC	PNTPLST	DEG_SCF_FBW7_1	0.1944
p.H3714Y	TCGA-D3-A51T	SKCM	TCGA	PNTPLST	DEG_SCF_FBW7_1	0.1389
p.H3714Y	DO229470	SKCA	ICGC	PNTPLST	DEG_SCF_FBW7_1	0.1389
p.H3714Y	DO218861	SKCA	ICGC	PNTPLST	DEG_SCF_FBW7_1	0.1389
p.H3714Y	DO47389	SKCM	ICGC	PNTPLST	DEG_SCF_FBW7_1	0.1389
p.S3711C	TCGA-FD-A6TC	BLCA	TCGA	PNTPLST	DEG_SCF_FBW7_1	0.0556
p.S3711C	DO49755	BLCA	ICGC	PNTPLST	DEG_SCF_FBW7_1	0.0556
p.S3726F	TCGA-GF-A6C9	SKCM	TCGA	PNTPLST	DEG_SCF_FBW7_1	0.6871
p.S3726F	DO51254	SKCM	ICGC	PNTPLST	DEG_SCF_FBW7_1	0.6871
p.S3726F	SIDM01106	Melanoma	GDSC	PNTPLST	DEG_SCF_FBW7_1	0.6871
p.S3726F	SIDM01768	Melanoma	GDSC	PNTPLST	DEG_SCF_FBW7_1	0.6871
p.S3726F	ACH-000822	Skin Cancer	CCLE	PNTPLST	DEG_SCF_FBW7_1	0.6871
p.S3726F	ACH-000899	Skin Cancer	CCLE	PNTPLST	DEG_SCF_FBW7_1	0.6871
p.S3726F	SK-MEL-24	skin	COSMIC	PNTPLST	DEG_SCF_FBW7_1	0.6871
p.T3712A	TCGA-GV-A3QH	BLCA	TCGA	PNTPLST	DEG_SCF_FBW7_1	0.0833
p.T3712A	DO464	BLCA	ICGC	PNTPLST	DEG_SCF_FBW7_1	0.0833
p.T3723M	DO230334	COCA	ICGC	PNTPLST	DEG_SCF_FBW7_1	0.7423
p.T3723M	DO229013	COCA	ICGC	PNTPLST	DEG_SCF_FBW7_1	0.7423
p.T3723M	DO229003	COCA	ICGC	PNTPLST	DEG_SCF_FBW7_1	0.7423
p.T3723M	DO229480	LAML	ICGC	PNTPLST	DEG_SCF_FBW7_1	0.7423
p.T3723M	DO229505	LAML	ICGC	PNTPLST	DEG_SCF_FBW7_1	0.7423
p.T3723M	DO228941	LICA	ICGC	PNTPLST	DEG_SCF_FBW7_1	0.7423
p.D3731A	DO228769	GACA	ICGC	PNTPLST	DEG_SCF_FBW7_1	0.2222
p.A3715S	DO233779	GACA	ICGC	PNTPLST	DEG_SCF_FBW7_1	0.1667
p.T3719N	DO229028	LICA	ICGC	PNTPLST	DEG_SCF_FBW7_1	0.2778
p.P3721Q	DO229028	LICA	ICGC	PNTPLST	DEG_SCF_FBW7_1	0.7035
p.L3736F	DO220895	MELA	ICGC	PNTPLST	DEG_SCF_FBW7_1	0.0833
p.D3737H	DO34640	PACA	ICGC	PNTPLST	DEG_SCF_FBW7_1	0.0556
p.T3717K	DO229479	SKCA	ICGC	PNTPLST	DEG_SCF_FBW7_1	0.2222
p.K3718T	SIDM01123	Prostate Carcinoma	GDSC	PNTPLST	DEG_SCF_FBW7_1	0.3611
p.K3718T	ACH-000177	Prostate Cancer	CCLE	PNTPLST	DEG_SCF_FBW7_1	0.3611
p.K3718T	NCI-H660	prostate	COSMIC	PNTPLST	DEG_SCF_FBW7_1	0.3611
p.T3717I	SIDM00815	Ovarian Carcinoma	GDSC	PNTPLST	DEG_SCF_FBW7_1	0.2222
p.T3717I	ACH-001418	Ovarian Cancer	CCLE	PNTPLST	DEG_SCF_FBW7_1	0.2222
p.T3717I	UWB1_289	ovary	COSMIC	PNTPLST	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PNTPLST

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PNTPLST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	3721:3727	PNTPLST	FBXW7	0.7529	More...