DegronMD

Uniprot ID: Q8NCK7

Source protein: Monocarboxylate transporter 11

Source gene: SLC16A11

Class: DEG_SCF_FBW7_2

Location: 438:445

E3 ligase: FBXW7

DEGRON score: 0.5427

ASA_SCORE: 96.675

COIL: 0.96

CONS_SCORE: 0.3772

DSS_SCORE: 0.7004

HELIX: 0.0243

FCONS_SCORE: 0.9509

RIG_SCORE: 0.5729

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P453S	TCGA-AX-A2H4	UCEC	TCGA	PPATPPPE	DEG_SCF_FBW7_2	0.1111
p.P453S	DO41193	UCEC	ICGC	PPATPPPE	DEG_SCF_FBW7_2	0.1111
p.G447R	TCGA-DA-A95V	SKCM	TCGA	PPATPPPE	DEG_SCF_FBW7_2	0.2778
p.G447R	DO219478	SKCM	ICGC	PPATPPPE	DEG_SCF_FBW7_2	0.2778
p.Q454K	TCGA-ER-A19T	SKCM	TCGA	PPATPPPE	DEG_SCF_FBW7_2	0.0833
p.T441K	DO229025	LICA	ICGC	PPATPPPE	DEG_SCF_FBW7_2	0.7306
p.E445A	SIDM00353	Other Sarcomas	GDSC	PPATPPPE	DEG_SCF_FBW7_2	0.7701
p.E445A	RKN	ovary	COSMIC	PPATPPPE	DEG_SCF_FBW7_2	0.7701
p.A455T	SIDM00013	Melanoma	GDSC	PPATPPPE	DEG_SCF_FBW7_2	0.0556
p.A455T	SIDM00710	Small Cell Lung Carcinoma	GDSC	PPATPPPE	DEG_SCF_FBW7_2	0.0556
p.A455T	ACH-000394	Lung Cancer	CCLE	PPATPPPE	DEG_SCF_FBW7_2	0.0556
p.A455T	NCI-H2081	lung	COSMIC	PPATPPPE	DEG_SCF_FBW7_2	0.0556
p.G429R	NCI-H630	large_intestine	COSMIC	PPATPPPE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NCK7	Monocarboxylate transporter 11	DEG_SCF_FBW7_2	438:445	PPATPPPE	FBXW7	0.5427	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons