DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
PPDTPPLS
Uniprot ID:
Q9Y5W3
Source protein:
Krueppel-like factor 2
Source gene:
KLF2
Class:
DEG_SCF_FBW7_1
Location:
170:177
E3 ligase:
FBXW7
DEGRON score:
0.9974
ASA_SCORE:
89.675
COIL:
0.969
CONS_SCORE:
0.5203
DSS_SCORE:
0.8795
HELIX:
0.0105
FCONS_SCORE:
1.4663
RIG_SCORE:
0.4878
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with KLF2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPDTPPLS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y5W3
Krueppel-like factor 2
DEG_SCF_FBW7_1
170:177
PPDTPPLS
FBXW7
0.9974
More...