DegronMD

Uniprot ID: Q8IZL8

Source protein: Proline-, glutamic acid- and leucine-rich protein 1

Source gene: PELP1

Class: DEG_SCF_FBW7_2

Location: 1079:1086

E3 ligase: FBXW7

DEGRON score: 0.9491

ASA_SCORE: 88.9125

COIL: 0.6623

CONS_SCORE: 0.3251

DSS_SCORE: 0.9554

HELIX: 0.3298

FCONS_SCORE: 1.0594

RIG_SCORE: 0.5798

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1077H	TCGA-06-5416	GBM	TCGA	PPETPAEE	DEG_SCF_FBW7_2	0.2778
p.P1083L	TCGA-55-8620	LUAD	TCGA	PPETPAEE	DEG_SCF_FBW7_2	0.7582
p.E1093D	TCGA-91-A4BC	LUAD	TCGA	PPETPAEE	DEG_SCF_FBW7_2	0.1389
p.E1070Q	TCGA-K4-A54R	BLCA	TCGA	PPETPAEE	DEG_SCF_FBW7_2	0.0833
p.A1095V	SIDM00523	Small Cell Lung Carcinoma	GDSC	PPETPAEE	DEG_SCF_FBW7_2	0.0833
p.A1095V	SIDM00806	Osteosarcoma	GDSC	PPETPAEE	DEG_SCF_FBW7_2	0.0833
p.A1095V	SIDM00085	Glioma	GDSC	PPETPAEE	DEG_SCF_FBW7_2	0.0833
p.E1092K	SIDM01051	Ovarian Carcinoma	GDSC	PPETPAEE	DEG_SCF_FBW7_2	0.1667
p.E1092K	EFO-27	ovary	COSMIC	PPETPAEE	DEG_SCF_FBW7_2	0.1667
p.A1096S	ACH-000913	Endometrial/Uterine Cancer	CCLE	PPETPAEE	DEG_SCF_FBW7_2	0.0556
p.A1096S	ESS-1	endometrium	COSMIC	PPETPAEE	DEG_SCF_FBW7_2	0.0556
p.T1090I	ACH-001063	Ovarian Cancer	CCLE	PPETPAEE	DEG_SCF_FBW7_2	0.6667
p.E1087Q	H513	pleura	COSMIC	PPETPAEE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZL8	Proline-, glutamic acid- and leucine-rich protein 1	DEG_SCF_FBW7_2	1079:1086	PPETPAEE	FBXW7	0.9491	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons