DegronMD - Q8IZL8(PELP1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E736K	TCGA-05-5428	LUAD	TCGA	PSGTPPPT	DEG_SCF_FBW7_1	742:749	Mutation rewiring degron network	0.1667
p.Q1077H	TCGA-06-5416	GBM	TCGA	PPETPAEE	DEG_SCF_FBW7_2	1079:1086	Mutation rewiring degron network	0.2778
p.P1083L	TCGA-55-8620	LUAD	TCGA	PPETPAEE	DEG_SCF_FBW7_2	1079:1086	Mutation altering degron motif	0.7582
p.D783N	TCGA-56-7822	LUSC	TCGA	SDSDDSVVIVPEGL	DEG_COP1_1	782:795	Mutation altering degron motif	0.6932
p.E1093D	TCGA-91-A4BC	LUAD	TCGA	PPETPAEE	DEG_SCF_FBW7_2	1079:1086	Mutation rewiring degron network	0.1389
p.I739T	TCGA-AA-3833	COAD	TCGA	PSGTPPPT	DEG_SCF_FBW7_1	742:749	Mutation rewiring degron network	0.25
p.G758W	TCGA-D3-A2JG	SKCM	TCGA	PSGTPPPT	DEG_SCF_FBW7_1	742:749	Mutation rewiring degron network	0.0833
p.G758W	TCGA-G7-6792	KIRP	TCGA	PSGTPPPT	DEG_SCF_FBW7_1	742:749	Mutation rewiring degron network	0.0833
p.P797L	TCGA-DM-A1D8	COAD	TCGA	SDSDDSVVIVPEGL	DEG_COP1_1	782:795	Mutation rewiring degron network	0.2778
p.L798M	TCGA-EE-A20F	SKCM	TCGA	SDSDDSVVIVPEGL	DEG_COP1_1	782:795	Mutation rewiring degron network	0.25
p.E1070Q	TCGA-K4-A54R	BLCA	TCGA	PPETPAEE	DEG_SCF_FBW7_2	1079:1086	Mutation rewiring degron network	0.0833
p.P755L	DO7828	COAD	ICGC	PSGTPPPT	DEG_SCF_FBW7_1	742:749	Mutation rewiring degron network	0.1667
p.A744V	DO230323	COCA	ICGC	PSGTPPPT	DEG_SCF_FBW7_1	742:749	Mutation altering degron motif	0.6936
p.I793T	DO231655	LINC	ICGC	SDSDDSVVIVPEGL	DEG_COP1_1	782:795	Mutation altering degron motif	0.7078
p.P743S	DO51259	SKCM	ICGC	PSGTPPPT	DEG_SCF_FBW7_1	742:749	Mutation altering degron motif	0.6752
p.K736N	DO229234	THCA	ICGC	PSGTPPPT	DEG_SCF_FBW7_1	742:749	Mutation rewiring degron network	0.1667
p.R781Q	SIDM01164	Glioma	GDSC	SDSDDSVVIVPEGL	DEG_COP1_1	782:795	Mutation rewiring degron network	0.3056
p.A1095V	SIDM00523	Small Cell Lung Carcinoma	GDSC	PPETPAEE	DEG_SCF_FBW7_2	1079:1086	Mutation rewiring degron network	0.0833
p.A1095V	SIDM00806	Osteosarcoma	GDSC	PPETPAEE	DEG_SCF_FBW7_2	1079:1086	Mutation rewiring degron network	0.0833
p.A1095V	SIDM00085	Glioma	GDSC	PPETPAEE	DEG_SCF_FBW7_2	1079:1086	Mutation rewiring degron network	0.0833
p.I800M	SIDM00878	Breast Carcinoma	GDSC	SDSDDSVVIVPEGL	DEG_COP1_1	782:795	Mutation rewiring degron network	0.1944
p.I800M	HCC1569	breast	COSMIC	SDSDDSVVIVPEGL	DEG_COP1_1	782:795	Mutation rewiring degron network	0.1944
p.A736S	SIDM00683	Prostate Carcinoma	GDSC	PSGTPPPT	DEG_SCF_FBW7_1	742:749	Mutation rewiring degron network	0.1667
p.A736S	LNCaP-Clone-FGC	prostate	COSMIC	PSGTPPPT	DEG_SCF_FBW7_1	742:749	Mutation rewiring degron network	0.1667
p.E1092K	SIDM01051	Ovarian Carcinoma	GDSC	PPETPAEE	DEG_SCF_FBW7_2	1079:1086	Mutation rewiring degron network	0.1667
p.E1092K	EFO-27	ovary	COSMIC	PPETPAEE	DEG_SCF_FBW7_2	1079:1086	Mutation rewiring degron network	0.1667
p.P802Q	SIDM00896	B-Cell Non-Hodgkin's Lymphoma	GDSC	SDSDDSVVIVPEGL	DEG_COP1_1	782:795	Mutation rewiring degron network	0.1389
p.P802Q	ACH-001322	Sarcoma	CCLE	SDSDDSVVIVPEGL	DEG_COP1_1	782:795	Mutation rewiring degron network	0.1389
p.P802Q	BC-1	haematopoietic and lymphoid tissue	COSMIC	SDSDDSVVIVPEGL	DEG_COP1_1	782:795	Mutation rewiring degron network	0.1389
p.H758D	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSGTPPPT	DEG_SCF_FBW7_1	742:749	Mutation rewiring degron network	0.0833
p.H758D	RL	haematopoietic and lymphoid tissue	COSMIC	PSGTPPPT	DEG_SCF_FBW7_1	742:749	Mutation rewiring degron network	0.0833
p.A1096S	ACH-000913	Endometrial/Uterine Cancer	CCLE	PPETPAEE	DEG_SCF_FBW7_2	1079:1086	Mutation rewiring degron network	0.0556
p.A1096S	ESS-1	endometrium	COSMIC	PPETPAEE	DEG_SCF_FBW7_2	1079:1086	Mutation rewiring degron network	0.0556
p.I750M	ACH-000930	Breast Cancer	CCLE	PSGTPPPT	DEG_SCF_FBW7_1	742:749	Mutation rewiring degron network	0.3056
p.I750M	HCC1569	breast	COSMIC	PSGTPPPT	DEG_SCF_FBW7_1	742:749	Mutation rewiring degron network	0.3056
p.T1090I	ACH-001063	Ovarian Cancer	CCLE	PPETPAEE	DEG_SCF_FBW7_2	1079:1086	Mutation blocking phosphorylation signal	0.6667
p.P752Q	ACH-002214	Lymphoma	CCLE	PSGTPPPT	DEG_SCF_FBW7_1	742:749	Mutation rewiring degron network	0.25
p.P752Q	BC-1	haematopoietic and lymphoid tissue	COSMIC	PSGTPPPT	DEG_SCF_FBW7_1	742:749	Mutation rewiring degron network	0.25
p.E786Q	KATOIII	stomach	COSMIC	SDSDDSVVIVPEGL	DEG_COP1_1	782:795	Mutation altering degron motif	0.6744
p.G757V	RCC-FG2	kidney	COSMIC	PSGTPPPT	DEG_SCF_FBW7_1	742:749	Mutation rewiring degron network	0.1111
p.E804D	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	SDSDDSVVIVPEGL	DEG_COP1_1	782:795	Mutation blocking phosphorylation signal	0.5278
p.D803E	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	SDSDDSVVIVPEGL	DEG_COP1_1	782:795	Mutation rewiring degron network	0.1111
p.E1087Q	H513	pleura	COSMIC	PPETPAEE	DEG_SCF_FBW7_2	1079:1086	Mutation rewiring degron network	0.3056
p.E804K	JSC-1	haematopoietic and lymphoid tissue	COSMIC	SDSDDSVVIVPEGL	DEG_COP1_1	782:795	Mutation blocking phosphorylation signal	0.5278

Kaplan plot for PELP1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PELP1

UniProt ID: Q8IZL8

Entrez ID: 27043

Protein name: Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PELP1 in