DegronMD

Uniprot ID: Q8IZL8

Source protein: Proline-, glutamic acid- and leucine-rich protein 1

Source gene: PELP1

Class: DEG_COP1_1

Location: 782:795

E3 ligase: COP1

DEGRON score: 0.982

ASA_SCORE: 87.0071

COIL: 0.9019

CONS_SCORE: 0.4955

DSS_SCORE: 0.642

HELIX: 0.0349

FCONS_SCORE: 1.2978

RIG_SCORE: 0.6776

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D783N	TCGA-56-7822	LUSC	TCGA	SDSDDSVVIVPEGL	DEG_COP1_1	0.6932
p.P797L	TCGA-DM-A1D8	COAD	TCGA	SDSDDSVVIVPEGL	DEG_COP1_1	0.2778
p.L798M	TCGA-EE-A20F	SKCM	TCGA	SDSDDSVVIVPEGL	DEG_COP1_1	0.25
p.I793T	DO231655	LINC	ICGC	SDSDDSVVIVPEGL	DEG_COP1_1	0.7078
p.R781Q	SIDM01164	Glioma	GDSC	SDSDDSVVIVPEGL	DEG_COP1_1	0.3056
p.I800M	SIDM00878	Breast Carcinoma	GDSC	SDSDDSVVIVPEGL	DEG_COP1_1	0.1944
p.I800M	HCC1569	breast	COSMIC	SDSDDSVVIVPEGL	DEG_COP1_1	0.1944
p.P802Q	SIDM00896	B-Cell Non-Hodgkin's Lymphoma	GDSC	SDSDDSVVIVPEGL	DEG_COP1_1	0.1389
p.P802Q	ACH-001322	Sarcoma	CCLE	SDSDDSVVIVPEGL	DEG_COP1_1	0.1389
p.P802Q	BC-1	haematopoietic_and_lymphoid_tissue	COSMIC	SDSDDSVVIVPEGL	DEG_COP1_1	0.1389
p.E786Q	KATOIII	stomach	COSMIC	SDSDDSVVIVPEGL	DEG_COP1_1	0.6744
p.E804D	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	SDSDDSVVIVPEGL	DEG_COP1_1	0.5278
p.D803E	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	SDSDDSVVIVPEGL	DEG_COP1_1	0.1111
p.E804K	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	SDSDDSVVIVPEGL	DEG_COP1_1	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZL8	Proline-, glutamic acid- and leucine-rich protein 1	DEG_COP1_1	782:795	SDSDDSVVIVPEGL	COP1	0.982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons