DegronMD

Uniprot ID: Q8IZL8

Source protein: Proline-, glutamic acid- and leucine-rich protein 1

Source gene: PELP1

Class: DEG_SCF_FBW7_1

Location: 742:749

E3 ligase: FBXW7

DEGRON score: 0.9954

ASA_SCORE: 83.025

COIL: 0.9729

CONS_SCORE: 0.3657

DSS_SCORE: 0.779

HELIX: 0.0099

FCONS_SCORE: 1.0118

RIG_SCORE: 0.5339

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E736K	TCGA-05-5428	LUAD	TCGA	PSGTPPPT	DEG_SCF_FBW7_1	0.1667
p.I739T	TCGA-AA-3833	COAD	TCGA	PSGTPPPT	DEG_SCF_FBW7_1	0.25
p.G758W	TCGA-D3-A2JG	SKCM	TCGA	PSGTPPPT	DEG_SCF_FBW7_1	0.0833
p.G758W	TCGA-G7-6792	KIRP	TCGA	PSGTPPPT	DEG_SCF_FBW7_1	0.0833
p.P755L	DO7828	COAD	ICGC	PSGTPPPT	DEG_SCF_FBW7_1	0.1667
p.A744V	DO230323	COCA	ICGC	PSGTPPPT	DEG_SCF_FBW7_1	0.6936
p.P743S	DO51259	SKCM	ICGC	PSGTPPPT	DEG_SCF_FBW7_1	0.6752
p.K736N	DO229234	THCA	ICGC	PSGTPPPT	DEG_SCF_FBW7_1	0.1667
p.A736S	SIDM00683	Prostate Carcinoma	GDSC	PSGTPPPT	DEG_SCF_FBW7_1	0.1667
p.A736S	LNCaP-Clone-FGC	prostate	COSMIC	PSGTPPPT	DEG_SCF_FBW7_1	0.1667
p.H758D	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSGTPPPT	DEG_SCF_FBW7_1	0.0833
p.H758D	RL	haematopoietic_and_lymphoid_tissue	COSMIC	PSGTPPPT	DEG_SCF_FBW7_1	0.0833
p.I750M	ACH-000930	Breast Cancer	CCLE	PSGTPPPT	DEG_SCF_FBW7_1	0.3056
p.I750M	HCC1569	breast	COSMIC	PSGTPPPT	DEG_SCF_FBW7_1	0.3056
p.P752Q	ACH-002214	Lymphoma	CCLE	PSGTPPPT	DEG_SCF_FBW7_1	0.25
p.P752Q	BC-1	haematopoietic_and_lymphoid_tissue	COSMIC	PSGTPPPT	DEG_SCF_FBW7_1	0.25
p.G757V	RCC-FG2	kidney	COSMIC	PSGTPPPT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZL8	Proline-, glutamic acid- and leucine-rich protein 1	DEG_SCF_FBW7_1	742:749	PSGTPPPT	FBXW7	0.9954	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons