DegronMD

Uniprot ID: A0JLT2

Source protein: Mediator of RNA polymerase II transcription subunit 19

Source gene: MED19

Class: DEG_SCF_FBW7_1

Location: 189:196

E3 ligase: FBXW7

DEGRON score: 0.9428

ASA_SCORE: 97.475

COIL: 0.9473

CONS_SCORE: 0.5512

DSS_SCORE: 0.8584

HELIX: 0.0406

FCONS_SCORE: 0.9771

RIG_SCORE: 0.4826

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T184I	DO233210	GACA	ICGC	PPETPSDS	DEG_SCF_FBW7_1	0.1944
p.Q181R	DO228357	LICA	ICGC	PPETPSDS	DEG_SCF_FBW7_1	0.1111
p.D195G	DO35442	PACA	ICGC	PPETPSDS	DEG_SCF_FBW7_1	0.6087
p.K191N	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PPETPSDS	DEG_SCF_FBW7_1	0.6918
p.K191N	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PPETPSDS	DEG_SCF_FBW7_1	0.6918
p.P190T	ACH-002105	Bone Cancer	CCLE	PPETPSDS	DEG_SCF_FBW7_1	0.5919

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0JLT2	Mediator of RNA polymerase II transcription subunit 19	DEG_SCF_FBW7_1	189:196	PPETPSDS	FBXW7	0.9428	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons