DegronMD

Uniprot ID: P51693

Source protein: Amyloid beta precursor like protein 1

Source gene: APLP1

Class: DEG_SCF_FBW7_1

Location: 212:219

E3 ligase: FBXW7

DEGRON score: 0.9904

ASA_SCORE: 76.85

COIL: 0.9353

CONS_SCORE: 0.3277

DSS_SCORE: 0.5372

HELIX: 0.02

FCONS_SCORE: 0.6557

RIG_SCORE: 0.5989

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V223A	TCGA-06-5416	GBM	TCGA	PPGTPDPS	DEG_SCF_FBW7_1	0.2222
p.R203H	TCGA-19-5956	GBM	TCGA	PPGTPDPS	DEG_SCF_FBW7_1	0.0833
p.R203H	TCGA-4Z-AA83	BLCA	TCGA	PPGTPDPS	DEG_SCF_FBW7_1	0.0833
p.R203H	ACH-002021	Endometrial/Uterine Cancer	CCLE	PPGTPDPS	DEG_SCF_FBW7_1	0.0833
p.R203C	TCGA-A6-2677	COAD	TCGA	PPGTPDPS	DEG_SCF_FBW7_1	0.0833
p.R203C	TCGA-CV-6960	HNSC	TCGA	PPGTPDPS	DEG_SCF_FBW7_1	0.0833
p.G214V	TCGA-A8-A07G	BRCA	TCGA	PPGTPDPS	DEG_SCF_FBW7_1	0.6421
p.R229Q	TCGA-AX-A3FT	UCEC	TCGA	PPGTPDPS	DEG_SCF_FBW7_1	0.0556
p.S219Y	TCGA-CJ-4639	KIRC	TCGA	PPGTPDPS	DEG_SCF_FBW7_1	0.712
p.P211L	TCGA-H9-7775	PRAD	TCGA	PPGTPDPS	DEG_SCF_FBW7_1	0.3056
p.P211L	SIDM00243	Other Solid Cancers	GDSC	PPGTPDPS	DEG_SCF_FBW7_1	0.3056
p.P211L	ACH-002288	Embryonal Cancer	CCLE	PPGTPDPS	DEG_SCF_FBW7_1	0.3056
p.P211L	NEC8	testis	COSMIC	PPGTPDPS	DEG_SCF_FBW7_1	0.3056
p.R229P	TCGA-SS-A7HO	COAD	TCGA	PPGTPDPS	DEG_SCF_FBW7_1	0.0556
p.G228E	DO51921	BLCA	ICGC	PPGTPDPS	DEG_SCF_FBW7_1	0.0833
p.G208V	DO2870	BRCA	ICGC	PPGTPDPS	DEG_SCF_FBW7_1	0.2222
p.S224Y	DO222404	BTCA	ICGC	PPGTPDPS	DEG_SCF_FBW7_1	0.1944
p.R223P	DO223705	COAD	ICGC	PPGTPDPS	DEG_SCF_FBW7_1	0.2222
p.P212T	DO233882	GACA	ICGC	PPGTPDPS	DEG_SCF_FBW7_1	0.7031
p.P212T	G-361	skin	COSMIC	PPGTPDPS	DEG_SCF_FBW7_1	0.7031
p.V217A	DO10880	GBM	ICGC	PPGTPDPS	DEG_SCF_FBW7_1	0.6936
p.S213Y	DO17791	KIRC	ICGC	PPGTPDPS	DEG_SCF_FBW7_1	0.712
p.P210S	DO51473	PACA	ICGC	PPGTPDPS	DEG_SCF_FBW7_1	0.2778
p.P205L	DO36354	PRAD	ICGC	PPGTPDPS	DEG_SCF_FBW7_1	0.1389
p.P205L	NEC8	testis	COSMIC	PPGTPDPS	DEG_SCF_FBW7_1	0.1389
p.P227L	DO229446	SKCA	ICGC	PPGTPDPS	DEG_SCF_FBW7_1	0.1111
p.R223Q	DO40801	UCEC	ICGC	PPGTPDPS	DEG_SCF_FBW7_1	0.2222
p.T215S	SIDM01649	Non-Cancerous	GDSC	PPGTPDPS	DEG_SCF_FBW7_1	0.7116
p.T215S	SIDM00345	Non-Small Cell Lung Carcinoma	GDSC	PPGTPDPS	DEG_SCF_FBW7_1	0.7116
p.T215S	SIDM01076	B-Lymphoblastic Leukemia	GDSC	PPGTPDPS	DEG_SCF_FBW7_1	0.7116
p.T215S	SIDM00184	Melanoma	GDSC	PPGTPDPS	DEG_SCF_FBW7_1	0.7116
p.P218T	SIDM00857	Melanoma	GDSC	PPGTPDPS	DEG_SCF_FBW7_1	0.5919
p.P218T	ACH-000572	Skin Cancer	CCLE	PPGTPDPS	DEG_SCF_FBW7_1	0.5919
p.P218T	G-361	skin	COSMIC	PPGTPDPS	DEG_SCF_FBW7_1	0.5919
p.G214E	SIDM01117	Small Cell Lung Carcinoma	GDSC	PPGTPDPS	DEG_SCF_FBW7_1	0.6087
p.G214E	ACH-002176	Lung Cancer	CCLE	PPGTPDPS	DEG_SCF_FBW7_1	0.6087
p.G214E	NCI-H748	lung	COSMIC	PPGTPDPS	DEG_SCF_FBW7_1	0.6087
p.D215N	MZ7-mel	skin	COSMIC	PPGTPDPS	DEG_SCF_FBW7_1	0.6932
p.Y207D	KMS-12-BM	haematopoietic_and_lymphoid_tissue	COSMIC	PPGTPDPS	DEG_SCF_FBW7_1	0.1944
p.E204D	TE-4	oesophagus	COSMIC	PPGTPDPS	DEG_SCF_FBW7_1	0.1111
p.E207D	HCT-15	large_intestine	COSMIC	PPGTPDPS	DEG_SCF_FBW7_1	0.1944
p.G208E	NCI-H748	lung	COSMIC	PPGTPDPS	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPGTPDPS

Degron related mutations and impact score

Drug responses associated with APLP1 mutations

All proteins holding degron of PPGTPDPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51693	Amyloid beta precursor like protein 1	DEG_SCF_FBW7_1	212:219	PPGTPDPS	FBXW7	0.9904	More...